NLRP2

NLR family, pyrin domain containing 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2KM6​
Identifiers
Symbols	NLRP2 ; CLR19.9; NALP2; NBS1; PAN1; PYPAF2
External IDs	OMIM: 609364 MGI: 3041206 HomoloGene: 56789 GeneCards: NLRP2 Gene
Gene ontology Molecular function • protein binding • ATP binding • Pyrin domain binding Cellular component • cytoplasm Biological process • inflammatory response • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • innate immune response • positive regulation of interleukin-1 beta secretion Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55655	232827
Ensembl	ENSG00000022556	ENSMUSG00000035177
UniProt	Q9NX02	Q4PLS0
RefSeq (mRNA)	NM_001174081	NM_177690
RefSeq (protein)	NP_001167552	NP_808358
Location (UCSC)	Chr 19: 54.95 – 55 Mb	Chr 7: 5.3 – 5.35 Mb
PubMed search

NACHT, LRR and PYD domains-containing protein 2 is a protein that in humans is encoded by the NLRP2 gene.^[1][2][3]

NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003).[supplied by OMIM]^[3]

References

1. Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287.
2. Bertin J, DiStefano PS (Mar 2001). "The PYRIN domain: a novel motif found in apoptosis and inflammation proteins". Cell Death Differ 7 (12): 1273–4. doi:10.1038/sj.cdd.4400774. PMID 11270363.
3. "Entrez Gene: NLRP2 NLR family, pyrin domain containing 2".

Further reading

• Teng SC, Wu KJ, Tseng SF, et al. (2007). "Importin KPNA2, NBS1, DNA repair and tumorigenesis.". J. Mol. Histol. 37 (5–7): 293–9. doi:10.1007/s10735-006-9032-y. PMID 16752129.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Martinon F, Hofmann K, Tschopp J (2001). "The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation". Curr. Biol. 11 (4): R118–20. doi:10.1016/S0960-9822(01)00056-2. PMID 11250163.
• Wang L, Manji GA, Grenier JM, et al. (2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J. Biol. Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.
• Grenier JM, Wang L, Manji GA, et al. (2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett. 530 (1–3): 73–8. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Agostini L, Martinon F, Burns K, et al. (2004). "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder". Immunity 20 (3): 319–25. doi:10.1016/S1074-7613(04)00046-9. PMID 15030775.
• Bruey JM, Bruey-Sedano N, Newman R, et al. (2005). "PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages". J. Biol. Chem. 279 (50): 51897–907. doi:10.1074/jbc.M406741200. PMID 15456791.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kinoshita T, Wang Y, Hasegawa M, et al. (2005). "PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion". J. Biol. Chem. 280 (23): 21720–5. doi:10.1074/jbc.M410057200. PMID 15817483.
• Rink L, Slupianek A, Stoklosa T, et al. (2007). "Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells". Blood 110 (2): 651–60. doi:10.1182/blood-2006-08-042630. PMC 1924483. PMID 17431132.