NLRP14
| NLR family, pyrin domain containing 14 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||
| Identifiers | |||||||||||||
| Symbols | NLRP14 ; CLR11.2; GC-LRR; NALP14; NOD5; PAN8 | ||||||||||||
| External IDs | OMIM: 609665 MGI: 1924108 HomoloGene: 18531 IUPHAR: 1781 GeneCards: NLRP14 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 338323 | 76858 | |||||||||||
| Ensembl | ENSG00000158077 | ENSMUSG00000016626 | |||||||||||
| UniProt | Q86W24 | Q6B966 | |||||||||||
| RefSeq (mRNA) | NM_176822 | NM_001002894 | |||||||||||
| RefSeq (protein) | NP_789792 | NP_001002894 | |||||||||||
| Location (UCSC) |
Chr 11: 7.02 – 7.07 Mb |
Chr 7: 107.17 – 107.2 Mb | |||||||||||
| PubMed search | |||||||||||||
NLRP14, short for NOD-like receptor family pyrin domain containing 14, is an intracellular protein of mammals associated with a role in spermatogenesis. It is also known as NALP14, NOD5, GC-LRR, Nalp-iota, PAN8, and CLR11.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.[1] NLRP14 is found exclusively in the testes where it is expressed within spermatogonia, spermatocytes and spermatids.[2]
References
- ↑ Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287.
- ↑ Westerveld GH, Korver CM, van Pelt AM, et al. (December 2006). "Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure". Hum. Reprod. 21 (12): 3178–84. doi:10.1093/humrep/del293. PMID 16931801.
Further reading
- Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885.
- Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis.". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
| ||||||||||||||||||
This article is issued from Wikipedia - version of the Tuesday, September 01, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.