| Name | North or east end | South or west end | U.S. Highways (approximate, based on 1926 plan and later additions) | Notes | 
|---|
| Albert Pike Highway | Hot Springs, Arkansas | Colorado Springs, Colorado | US 270, US 64, US 183, US 154, US 50, US 85 | 
| Arrowhead Trail | Salt Lake City, Utah | Los Angeles, California | US 91 | 
| Atlantic Highway | Calais, Maine | Miami, Florida | US 1, US 25, US 17, US 1 | 
| Atlantic-Pacific Highway | New York, New York | Los Angeles, California | US 1, US 211, US 15, US 33, US 60, US 52, US 460, US 50, US 54, US 70, US 60 | 
| Atlantic Yellowstone Pacific Highway | Chicago, Illinois | Sioux Falls, South Dakota | US 20, US 218, US 18 | 
| Baltimore Pike | Baltimore, Maryland | Philadelphia, Pennsylvania |  | 
| Bankhead Highway | Washington, D.C. | San Diego, California | US 1, US 15, US 70, US 170, US 29, US 78, US 70, US 67, US 80 | 
| Bee Line Highway | Chicago, Illinois | New Orleans, Louisiana |  | 
| Ben Hur Highway | St. Louis, Missouri | Fort Dodge, Iowa |  | 
| Black and Yellow Trail | Chicago, Illinois | Yellowstone National Park | US 41, US 16, US 14, US 16, US 20 | 
| Blackhawk Highway | Dixon, Illinois | Beloit, Wisconsin | IL 2, IL 251, US 51 | 
| California-Banff Bee Line |  |  |  | 
| Cannon Ball Route | Chicago, Illinois | Hannibal, Missouri |  | 
| Capital Route | Omaha, Nebraska | Austin, Texas |  | 
| Chicago, Kansas City and Gulf Highway | Chicago, Illinois | Galveston, Texas |  | 
| Colorado to Gulf Highway | Denver, Colorado | Galveston, Texas and Brownsville, Texas | US 85, US 385, US 370, US 81, US 181 | 
| Columbia River Highway | Pendleton, Oregon | Portland, Oregon | US 30 | 
| Cooley Highway | Grand Rapids, Minnesota | Sisseton, South Dakota |  | 
| Cornhusker Highway | Sioux City, Iowa | Oklahoma City, Oklahoma |  | 
| Custer Battlefield Highway | Omaha, Nebraska | Glacier National Park | US 75, US 16, US 116, US 87E, US 87 | 
| Dallas-Canadian-Denver Highway | Boulder, Colorado | Galveston, Texas | US 85, US 50, US 83, US 70, US 77 | 
| Daniel Webster Highway |  |  |  | 
| Detroit-Lincoln-Denver Highway | Detroit, Michigan | Denver, Colorado | US 12, US 32, US 38 | 
| Dixie Highway | Chicago, Illinois and Sault Ste. Marie, Michigan | Miami, Florida | Illinois 1, US 136, US 31, Indiana 37, US 150, US 31W | 
| Dixie Bee Line | Chicago, Illinois | Nashville, Tennessee | US 41, US 241 | 
| Dixie Overland Highway | Savannah, Georgia | San Diego, California | US 80, US 84, US 380, US 366, US 80 | 
| Evergreen National Highway | Victoria, British Columbia | El Paso, Texas | US 99, US 10, US 97, US 410, US 95, US 30, US 30N, US 91, US 95, US 66 | 
| Egyptian Trail | Chicago, Illinois | Cairo, Illinois |  | 
| Florida Short Route |  |  |  | 
| George Washington National Highway | Savannah, Georgia | Seattle, Washington |  | 
| Geysers-to-Glaciers Highway | Glacier National Park | Yellowstone National Park | US 89 W from West Yellowstone to Shelby, Montana; US 2 from Shelby to Cut Bank, Montana; and MT 213 from Cut Bank to the Canadian border[1] | 
| Glacier to Gulf Motorway | Calgary, Alberta | Tampico, Mexico |  | 
| Glacier Trail | Seattle, Washington | Jacksonville, Florida |  | 
| Grant Highway | Chicago, Illinois | Portland, Oregon | US 20 | 
| Great White Way | Davenport, Iowa | Council Bluffs, Iowa |  | 
| International Peace Highway | Quebec, Quebec and Rouses Point, New York | Laredo, Texas and Mexico City, Mexico |  | 
| Jackson Highway | Chicago, Illinois | New Orleans, Louisiana | US 152, US 52, US 31, US 168, US 68, US 31, US 43, US 45, US 11 | 
| Jefferson Highway | Winnipeg, Manitoba | New Orleans, Louisiana | US 59, US 2, US 71, US 10N, US 10, US 65, US 69, US 71/US 73E, US 73, US 75, US 69, US 67, US 271, US 80, US 171, US 71, US 61 | 
| Jefferson Davis National Highway | Washington, D.C. | San Diego, California | US 1, US 278, US 29, US 80, US 43, US 90, US 96, US 277, US 90 | 
| King of Trails | Winnipeg, Manitoba | Galveston, Texas and Brownsville, Texas | US 75/US 81, US 75/US 77, US 75, US 73, US 73E, US 50, US 73W, US 75, US 77, US 81, US 181, US 96 | 
| Lackawanna Trail | Binghamton, New York | Delaware, New Jersey | US 11,[2] US 611[3] | 
| Lakes to Gulf Highway | Duluth, Minnesota | Galveston, Texas |  | 
| Lakes-to-Sea Highway | Atlantic City, New Jersey | Erie, Pennsylvania | US 30, US 120, US 22, US 322, US 19 | 
| Lee Highway | New York, New York | San Francisco, California | US 1, US 211, US 11, US 72, US 70, US 366, US 80, US 180, US 80, US 101 | 
| Lewis and Clark Highway | Missoula, Montana | Lewiston, Idaho |  | 
| Liberty Highway | New York, New York | Cleveland, Ohio | New Jersey 4, New Jersey 17, New York 17, New York 430, New York 394, US 20[4] | 
| Lincoln Highway | New York, New York | San Francisco, California | US 1, US 30, US 40, US 93, US 50, US 99, US 48 | 
| Logan-Lee Highway | Rock Island, Illinois | Paducah, Kentucky | US 67, Illinois 3 | 
| Lone Star Route | Chicago, Illinois | Lake Charles, Louisiana (earlier Brownsville, Texas) | US 66, US 67, US 63, US 165 | 
| Lone Star Trail | St. Augustine, Florida | Los Angeles, California | US 1, US 90, US 84, US 67, US 290, US 80 | 
| Magnolia Route |  |  |  | 
| Meridian Highway | Winnipeg, Manitoba | Mexico City, Mexico | US 81 | 
| Mississippi River Scenic Highway | Winnipeg, Manitoba and Port Arthur, Ontario | Fort Myers, Florida and Port Arthur, Texas | US 75, US 2, US 71, US 10N, US 10, US 61, US 55, US 61, US 90; US 49E, US 49, US 98, US 90, US 19, US 41 | 
| Mississippi Valley Highway | Ely, Minnesota | Gulfport, Mississippi (earlier New Orleans, Louisiana) | US 53, US 61, US 55, US 161, US 67, US 51, US 45, US 11, US 49 | Earlier known as the Burlington Way | 
| National Old Trails Road | Washington, D.C. and Baltimore, Maryland | Los Angeles, California | US 240/US 40, US 40, US 50N, US 50, US 350, US 85, US 70, US 66 | 
| National Park-to-Park Highway | Loop connecting National Parks |  | US 99, US 48, US 40, US 99E, US 99, US 10, US 195, US 95, US 2, US 87, US 87W, US 20, US 185, US 85, US 50, US 285, US 450, US 550, US 64, US 666, US 66 | 
| National Parks Highway | Boston, Massachusetts and New York, New York | Seattle, Washington |  | Also known as the Northwest Trail | 
| National Roosevelt Midland Trail | Washington, D.C. and Newport News, Virginia (earlier Oyster Bay, New York) | Los Angeles, California | US 60, US 150, US 50, US 40, US 40N, US 40, US 40S, US 50, US 6 | 
| National White Way |  |  |  | 
| New Santa Fe Trail | Kansas City, Mo. | Los Angeles | US 50, US 350, US 85, US 66 | 
| Old Oregon Trail | Independence, Missouri | Seaside, Oregon and Olympia, Washington | US 40, US 30, US 26, US 20, US 87E, US 30N, US 30 | 
| Old Spanish Trail | St. Augustine, Florida | San Diego, California | US 1, US 90, US 80 | 
| Ozark Trails | Kansas City, Missouri, Hannibal, Missouri, St. Louis, Missouri, and Memphis, Tennessee | Denver, Colorado, Las Vegas, New Mexico, and El Paso, Texas |  | 
| Pacific Highway | Vancouver, British Columbia | San Diego, California | US 99, US 40, US 101 | 
| Pershing Way | Winnipeg, Manitoba | New Orleans, Louisiana |  | 
| Pikes Peak Ocean to Ocean Highway | New York, New York | Los Angeles, California (earlier San Francisco, California) | US 22, US 250, US 36, US 136, US 36, US 40N, US 40S, US 50, US 91 | Also known as the Pershing Transport Route | 
| Puget Sound-to-Gulf Highway |  |  |  | 
| Red Ball Route |  |  |  | 
| River-to-River Road | Davenport, Iowa | Council Bluffs, Iowa |  | 
| Southern National Highway |  |  |  | 
| Southwest Trail | Chicago, Illinois | El Paso, Texas | US 32, US 65, US 50S, US 81, US 160, US 281, US 60, US 366 | 
| Susquehanna Trail | Buffalo, New York | Washington, D.C. | US 20, US 15, US 111/US 240 | 
| Theodore Roosevelt International Highway | Portland, Maine | Portland, Oregon | US 302, US 2, US 11, US 104, US 23, US 2, US 95, US 195, US 295, US 410, US 30 | 
| Three C Highway | Cleveland, Ohio | Cincinnati, Ohio | US 42 | 
| Transprovincial Highway | Ottawa | Toronto |  | Later Ontario Highway 2 and Ontario Highway 15 | 
| Victory Highway | New York, New York | San Francisco, California | US 1, US 40, US 40S, US 83, US 40N, US 40 | 
| White River Trail | Springfield, Missouri | Ponca City, Oklahoma |  | 
| White-way 7 Highway | Chicago, Illinois | Omaha, Nebraska | US 32 | In Iowa, created from segments of the River to River Road from Davenport to Redfield, and the Great White Way from Dexter to Council Bluffs. | 
| William Penn Highway | New York, New York | Pittsburgh, Pennsylvania | US 22 | 
| Yellowstone Highway | Denver, Colorado | Yellowstone National Park |  | 
| Yellowstone Trail | Plymouth, Massachusetts | Seattle, Washington | US 20, US 30, US 41, US 110, US 10, US 212, US 12, US 10, US 195, US 295, US 410, US 97, US 10 |