PLCE1

Phospholipase C, epsilon 1
PDB rendering based on 2bye.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2BYE​, 2BYF​, 2C5L​
Identifiers
Symbols	PLCE1 ; NPHS3; PLCE; PPLC
External IDs	OMIM: 608414 MGI: 1921305 HomoloGene: 9478 ChEMBL: 3282 GeneCards: PLCE1 Gene
EC number	3.1.4.11
Gene ontology Molecular function • phosphatidylinositol phospholipase C activity • phospholipase C activity • receptor signaling protein activity • guanyl-nucleotide exchange factor activity • protein binding • Ras GTPase binding • enzyme binding Cellular component • Golgi membrane • cytoplasm • cytosol • plasma membrane Biological process • activation of MAPK activity • regulation of cell growth • phospholipid metabolic process • diacylglycerol biosynthetic process • regulation of smooth muscle contraction • cytoskeleton organization • epidermal growth factor receptor signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • protein kinase C-activating G-protein coupled receptor signaling pathway • Ras protein signal transduction • heart development • regulation of G-protein coupled receptor protein signaling pathway • cell proliferation • lipid catabolic process • calcium-mediated signaling • glomerulus development • positive regulation of GTPase activity • inositol phosphate metabolic process • small molecule metabolic process • regulation of protein kinase activity • regulation of Ras protein signal transduction • inositol phosphate-mediated signaling Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51196	74055
Ensembl	ENSG00000138193	ENSMUSG00000024998
UniProt	Q9P212	Q8K4S1
RefSeq (mRNA)	NM_001165979	NM_019588
RefSeq (protein)	NP_001159451	NP_062534
Location (UCSC)	Chr 10: 93.99 – 94.33 Mb	Chr 19: 38.48 – 38.79 Mb
PubMed search

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1 is an enzyme that in humans is encoded by the PLCE1 gene.^[1][2][3]

Function

PLCE1 belongs to the phospholipase family that catalyzes the hydrolysis of polyphosphoinositides such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) to generate the second messengers Ins(1,4,5)P3 and diacylglycerol. These products initiate a cascade of intracellular responses that result in cell growth and differentiation and gene expression.[supplied by OMIM]^[3]

References

1. Lopez I, Mak EC, Ding J, Hamm HE, Lomasney JW (May 2001). "A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway". J Biol Chem 276 (4): 2758–65. doi:10.1074/jbc.M008119200. PMID 11022047.
2. Song C, Hu CD, Masago M, Kariyai K, Yamawaki-Kataoka Y, Shibatohge M, Wu D, Satoh T, Kataoka T (May 2001). "Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras". J Biol Chem 276 (4): 2752–7. doi:10.1074/jbc.M008324200. PMID 11022048.
3. "Entrez Gene: PLCE1 phospholipase C, epsilon 1".

Further reading

• Jefferson JA, Shankland SJ (2007). "Familial nephrotic syndrome: PLCE1 enters the fray.". Nephrol. Dial. Transplant. 22 (7): 1849–52. doi:10.1093/ndt/gfm098. PMID 17449496.
• Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339.
• Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.". Eur. J. Immunol. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMID 7589147.
• Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385.
• Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.". Neuroimmunomodulation 5 (3–4): 184–92. doi:10.1159/000026336. PMID 9730685.
• Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179.
• Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
• Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
• Jin TG, Satoh T, Liao Y, Song C, Gao X, Kariya K, Hu CD, Kataoka T (2001). "Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling". J. Biol. Chem. 276 (32): 30301–7. doi:10.1074/jbc.M103530200. PMID 11395506.
• Schmidt M, Evellin S, Weernink PA, von Dorp F, Rehmann H, Lomasney JW, Jakobs KH (2001). "A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase". Nat. Cell Biol. 3 (11): 1020–4. doi:10.1038/ncb1101-1020. PMID 11715024.
• Evellin S, Nolte J, Tysack K, vom Dorp F, Thiel M, Weernink PA, Jakobs KH, Webb EJ, Lomasney JW, Schmidt M (2002). "Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B". J. Biol. Chem. 277 (19): 16805–13. doi:10.1074/jbc.M112024200. PMID 11877431.
• Song C, Satoh T, Edamatsu H, Wu D, Tadano M, Gao X, Kataoka T (2002). "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon". Oncogene 21 (53): 8105–13. doi:10.1038/sj.onc.1206003. PMID 12444546.
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
• Czyzyk J, Brogdon JL, Badou A, Henegariu O, Preston Hurlburt P, Flavell R, Bottomly K (2003). "Activation of CD4 T cells by Raf-independent effectors of Ras". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6003–8. doi:10.1073/pnas.1031494100. PMC 156316. PMID 12721365.
• Lennartsson J, Wernstedt C, Engström U, Hellman U, Rönnstrand L (2003). "Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk". Exp. Cell Res. 288 (1): 110–8. doi:10.1016/S0014-4827(03)00206-4. PMID 12878163.
• vom Dorp F, Sari AY, Sanders H, Keiper M, Oude Weernink PA, Jakobs KH, Schmidt M (2005). "Inhibition of phospholipase C-epsilon by Gi-coupled receptors". Cell. Signal. 16 (8): 921–8. doi:10.1016/j.cellsig.2004.01.009. PMID 15157671.