Protein phosphatase methylesterase-1

Protein phosphatase methylesterase-1 (EC 3.1.1.89, PME-1, PPME1) is an enzyme with systematic name (phosphatase 2A protein)-leucine ester acylhydrolase.^[1]^[2] This enzyme catalyses the following chemical reaction

[phosphatase 2A protein]-leucine methyl ester + H₂O

\rightleftharpoons

[phosphatase 2A protein]-leucine + methanol

A key regulator of protein phosphatase 2A.

References

↑ Ogris, E., Du, X., Nelson, K.C., Mak, E.K., Yu, X.X., Lane, W.S. and Pallas, D.C. (1999). "A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A". J. Biol. Chem. 274 (20): 14382–14391. doi:10.1074/jbc.274.20.14382. PMC 3503312. PMID 10318862.
↑ Xing, Y., Li, Z., Chen, Y., Stock, J.B., Jeffrey, P.D. and Shi, Y. (2008). "Structural mechanism of demethylation and inactivation of protein phosphatase 2A". Cell 133 (1): 154–163. doi:10.1016/j.cell.2008.02.041. PMID 18394995.

External links

Protein phosphatase methylesterase-1 at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4: Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease and
ribonuclease)

3.1.11-16: Exonuclease

Exodeoxyribonuclease	RecBCD

Exoribonuclease	Oligonucleotidase

3.1.21-31: Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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