Pimelyl-(acyl-carrier protein) methyl ester esterase

Pimelyl-(acyl-carrier protein) methyl ester esterase (EC 3.1.1.85, BioH) is an enzyme with systematic name pimelyl-(acyl-carrier protein) methyl ester hydrolase.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

pimelyl-[acyl-carrier protein] methyl ester + H₂O

\rightleftharpoons

pimelyl-[acyl-carrier protein] + methanol

This enzyme takes part in biotin biosynthesis in Gram-negative bacteria.

References

↑ Sanishvili, R., Yakunin, A.F., Laskowski, R.A., Skarina, T., Evdokimova, E., Doherty-Kirby, A., Lajoie, G.A., Thornton, J.M., Arrowsmith, C.H., Savchenko, A., Joachimiak, A. and Edwards, A.M. (2003). "Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli". J. Biol. Chem. 278: 26039–26045. doi:10.1074/jbc.M303867200. PMID 12732651.
↑ Lemoine, Y., Wach, A. and Jeltsch, J.M. (1996). "To be free or not: the fate of pimelate in Bacillus sphaericus and in Escherichia coli". Mol. Microbiol. 19 (3): 645–647. doi:10.1046/j.1365-2958.1996.t01-4-442924.x. PMID 8830257.
↑ Tomczyk, N.H., Nettleship, J.E., Baxter, R.L., Crichton, H.J., Webster, S.P. and Campopiano, D.J. (2002). "Purification and characterisation of the BIOH protein from the biotin biosynthetic pathway". FEBS Lett. 513 (2-3): 299–304. doi:10.1016/s0014-5793(02)02342-6. PMID 11904168.
↑ Lin, S., Hanson, R.E. and Cronan, J.E. (2010). "Biotin synthesis begins by hijacking the fatty acid synthetic pathway". Nat. Chem. Biol. 6 (9): –. doi:10.1038/nchembio.420. PMC 2925990. PMID 20693992.

External links

Pimelyl-(acyl-carrier protein) methyl ester esterase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4: Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease and
ribonuclease)

3.1.11-16: Exonuclease

Exodeoxyribonuclease	RecBCD

Exoribonuclease	Oligonucleotidase

3.1.21-31: Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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