Pyrethroid hydrolase

Pyrethroid hydrolase
Identifiers
EC number	3.1.1.88
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Pyrethroid hydrolase (EC 3.1.1.88, pyrethroid-hydrolyzing carboxylesterase, pyrethroid-hydrolysing esterase, pyrethroid-hydrolyzing esterase, pyrethroid-selective esterase, pyrethroid-cleaving enzyme, permethrinase, PytH, EstP) is an enzyme with systematic name pyrethroid-ester hydrolase.^{[1][2][3][4][5][6]} This enzyme catalyses the following chemical reaction

trans-permethrin + H₂O $\rightleftharpoons$ (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

The enzyme is involved in degradation of pyrethroid pesticides.

References

1. Wang, B.Z., Guo, P., Hang, B.J., Li, L., He, J. and Li, S.P. (2009). "Cloning of a novel pyrethroid-hydrolyzing carboxylesterase gene from Sphingobium sp. strain JZ-1 and characterization of the gene product". Appl. Environ. Microbiol. 75: 5496–5500. doi:10.1128/aem.01298-09. PMID 19581484.
2. Wu, P.C., Liu, Y.H., Wang, Z.Y., Zhang, X.Y., Li, H., Liang, W.Q., Luo, N., Hu, J.M., Lu, J.Q., Luan, T.G. and Cao, L.X. (2006). "Molecular cloning, purification, and biochemical characterization of a novel pyrethroid-hydrolyzing esterase from Klebsiella sp. strain ZD112". J. Agric. Food Chem. 54: 836–842. doi:10.1021/jf052691u. PMID 16448191.
3. Liang, W.Q., Wang, Z.Y., Li, H., Wu, P.C., Hu, J.M., Luo, N., Cao, L.X. and Liu, Y.H. (2005). "Purification and characterization of a novel pyrethroid hydrolase from Aspergillus niger ZD11". J. Agric. Food Chem. 53: 7415–7420. doi:10.1021/jf051460k. PMID 16159167.
4. Stok, J.E., Huang, H., Jones, P.D., Wheelock, C.E., Morisseau, C. and Hammock, B.D. (2004). "Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes". J. Biol. Chem. 279: 29863–29869. doi:10.1074/jbc.m403673200. PMID 15123619.
5. Maloney, S.E., Maule, A. and Smith, A.R. (1993). "Purification and preliminary characterization of permethrinase from a pyrethroid-transforming strain of Bacillus cereus". Appl. Environ. Microbiol. 59: 2007–2013. PMID 8357241.
6. Guo, P., Wang, B., Hang, B., Li, L., Ali, W., He, J. and Li, S. (2009). "Pyrethroid-degrading Sphingobium sp. JZ-2 and the purification and characterization of a novel pyrethroid hydrolase". Int. Biodeter. Biodegrad. 63: 1107–1112. doi:10.1016/j.ibiod.2009.09.008.

External links

• Pyrethroid hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)