Ribonuclease U2

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Ribonuclease U2 (EC 3.1.27.4, purine specific endoribonuclease, ribonuclease U3, RNase U3, RNase U2, purine-specific ribonuclease, purine-specific RNase, Pleospora RNase, Trichoderma koningi RNase III, ribonuclease (purine)) is an enzyme.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

Two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphate intermediates

References

↑ Glitz, D.G. and Dekker, C.A. (1964). "Studies on a ribonuclease from Ustilago sphaerogena. I. Purification and properties of the enzyme". Biochemistry 3 (10): 1391–1399. doi:10.1021/bi00898a001. PMID 14230791.
↑ Glitz, D.G. and Dekker, C.A. (1964). "Studies on a ribonuclease from Ustilago sphaerogena. II. Specificity of the enzyme". Biochemistry 3 (10): 1399–1406. doi:10.1021/bi00898a002. PMID 14230792.
↑ Uchida, T. and Egami, F. Microbial ribonucleases with special reference to RNases T1, T 2, N (1971). "1, and U2". In Boyer, P.D. The Enzymes 4 (3rd ed.). New York: Academic Press. pp. 205–250.

External links

Ribonuclease U2 at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4: Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease and
ribonuclease)

3.1.11-16: Exonuclease

Exodeoxyribonuclease	RecBCD

Exoribonuclease	Oligonucleotidase

3.1.21-31: Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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