Steryl-sulfatase

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Steryl-sulfatase (EC 3.1.6.2, arylsulfatase, steroid sulfatase, sterol sulfatase, dehydroepiandrosterone sulfate sulfatase, arylsulfatase C, steroid 3-sulfatase, steroid sulfate sulfohydrolase, dehydroepiandrosterone sulfatase, pregnenolone sulfatase, phenolic steroid sulfatase, 3-beta-hydroxysteroid sulfate sulfatase) is an enzyme with systematic name steryl-sulfate sulfohydrolase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

3beta-hydroxyandrost-5-en-17-one 3-sulfate + H₂O

\rightleftharpoons

3beta-hydroxyandrost-5-en-17-one + sulfate

Also acts on some related steryl sulfates.

References

↑ Roy, A.B. (1954). "The steroid sulphatase of Patella vlugata". Biochim. Biophys. Acta 15: 300–301. doi:10.1016/0006-3002(54)90078-5. PMID 13208702.
↑ Roy, A.B. (1960). "The synthesis and hydrolysis of sulfate esters". Adv. Enzymol. Relat. Subj. Biochem. 22: 205–235. PMID 13744184.
↑ Stitch, S.R., Halkerston, I.D.K. and Hillman, J. (1965). "The enzymic hydrolysis of steroid conjugates. 1. Sulphatase and β-glucuronidase activity of molluscan extracts". Biochem. J. 63: 705–710. PMID 13355874.

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Steryl-sulfatase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4: Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease and
ribonuclease)

3.1.11-16: Exonuclease

Exodeoxyribonuclease	RecBCD

Exoribonuclease	Oligonucleotidase

3.1.21-31: Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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Steryl-sulfatase

See also

References

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