ADP-ribosylarginine hydrolase

(Protein ADP-ribosylarginine) hydrolase
Identifiers
EC number	3.2.2.19
CAS number	98668-52-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

(Protein ADP-ribosylarginine) hydrolase (EC 3.2.2.19, ADP-ribose-L-arginine cleavage enzyme, Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase, protein-omega-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase) is an enzyme with systematic name protein-Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase.^{[1][2][3][4][5]} This enzyme catalyses the following chemical reaction

(1) protein-Nomega-(ADP-D-ribosyl)-L-arginine + H₂O $\rightleftharpoons$ ADP-ribose + protein-L-arginine

(2) Nomega-(ADP-D-ribosyl)-L-arginine + H₂O $\rightleftharpoons$ ADP-ribose + L-arginine

The enzyme will remove ADP-ribose from arginine residues in ADP-ribosylated proteins.

References

1. Moss, J., Jacobson, M.K. and Stanley, S.J. (1985). "Reversibility of arginine-specific mono(ADP-ribosyl)ation: identification in erythrocytes of an ADP-ribose-L-arginine cleavage enzyme". Proc. Natl. Acad. Sci. USA 82 (17): 5603–5607. doi:10.1073/pnas.82.17.5603. PMID 2994036.
2. Moss, J., Stanley, S.J., Nightingale, M.S., Murtagh, J.J., Jr., Monaco, L., Mishima, K., Chen, H.C., Williamson, K.C. and Tsai, S.C. (1992). "Molecular and immunological characterization of ADP-ribosylarginine hydrolases". J. Biol. Chem. 267 (15): 10481–10488. PMID 1375222.
3. Konczalik, P. and Moss, J. (1999). "Identification of critical, conserved vicinal aspartate residues in mammalian and bacterial ADP-ribosylarginine hydrolases". J. Biol. Chem. 274 (24): 16736–16740. doi:10.1074/jbc.274.24.16736. PMID 10358013.
4. Takada, T., Iida, K. and Moss, J. (1993). "Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase". J. Biol. Chem. 268 (24): 17837–17843. PMID 8349667.
5. Ohno, T., Tsuchiya, M., Osago, H., Hara, N., Jidoi, J. and Shimoyama, M. (1995). "Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase". Anal. Biochem. 10 (1): 115–122. doi:10.1006/abio.1995.1510. PMID 8678289.

External links

• (protein ADP-ribosylarginine) hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)