Brevican

Brevican
Identifiers
Symbols	BCAN ; BEHAB; CSPG7
External IDs	OMIM: 600347 MGI: 1096385 HomoloGene: 7244 GeneCards: BCAN Gene
Gene ontology Molecular function • hyaluronic acid binding • carbohydrate binding Cellular component • extracellular region • proteinaceous extracellular matrix • extracellular space • Golgi lumen • dendrite • anchored component of membrane • lysosomal lumen • synapse Biological process • skeletal system development • carbohydrate metabolic process • cell adhesion • central nervous system development • hippocampus development • extracellular matrix disassembly • extracellular matrix organization • glycosaminoglycan metabolic process • chondroitin sulfate metabolic process • chondroitin sulfate biosynthetic process • chondroitin sulfate catabolic process • dermatan sulfate biosynthetic process • small molecule metabolic process • regulation of neuronal synaptic plasticity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	63827	12032
Ensembl	ENSG00000132692	ENSMUSG00000004892
UniProt	Q96GW7	Q61361
RefSeq (mRNA)	NM_021948	NM_001109758
RefSeq (protein)	NP_068767	NP_001103228
Location (UCSC)	Chr 1: 156.64 – 156.66 Mb	Chr 3: 87.99 – 88 Mb
PubMed search

Brevican core protein is a protein that in humans is encoded by the BCAN gene.^[1][2][3] Brevican is a member of the lectican protein family.

Brevican is localised to the surface of neurons in the brain.^[4] In melanocytic cells, BCAN gene expression may be regulated by MITF.^[5]

References

1. Gary SC, Zerillo CA, Chiang VL, Gaw JU, Gray G, Hockfield S (Oct 2000). "cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma". Gene 256 (1-2): 139–47. doi:10.1016/S0378-1119(00)00362-0. PMID 11054543.
2. Nomoto H, Oohashi T, Hirakawa S, Ueki Y, Ohtsuki H, Ninomiya Y (Feb 2002). "Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23". Acta Medica Okayama 56 (1): 25–9. PMID 11873941.
3. "Entrez Gene: BCAN brevican".
4. Frischknecht R, Seidenbecher CI (Jul 2012). "Brevican: a key proteoglycan in the perisynaptic extracellular matrix of the brain". The International Journal of Biochemistry & Cell Biology 44 (7): 1051–4. doi:10.1016/j.biocel.2012.03.022. PMID 22537913.
5. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading

• Hu B, Kong LL, Matthews RT, Viapiano MS (Sep 2008). "The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility". The Journal of Biological Chemistry 283 (36): 24848–59. doi:10.1074/jbc.M801433200. PMC 3259830. PMID 18611854.
• Seidenbecher CI, Richter K, Rauch U, Fässler R, Garner CC, Gundelfinger ED (Nov 1995). "Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms". The Journal of Biological Chemistry 270 (45): 27206–12. doi:10.1074/jbc.270.45.27206. PMID 7592978.
• Aspberg A, Miura R, Bourdoulous S, Shimonaka M, Heinegârd D, Schachner M, Ruoslahti E, Yamaguchi Y (Sep 1997). "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety". Proceedings of the National Academy of Sciences of the United States of America 94 (19): 10116–21. doi:10.1073/pnas.94.19.10116. PMC 23322. PMID 9294172.
• Nakamura H, Fujii Y, Inoki I, Sugimoto K, Tanzawa K, Matsuki H, Miura R, Yamaguchi Y, Okada Y (Dec 2000). "Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites". The Journal of Biological Chemistry 275 (49): 38885–90. doi:10.1074/jbc.M003875200. PMID 10986281.
• Olin AI, Mörgelin M, Sasaki T, Timpl R, Heinegård D, Aspberg A (Jan 2001). "The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding". The Journal of Biological Chemistry 276 (2): 1253–61. doi:10.1074/jbc.M006783200. PMID 11038354.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Xu XM, Chen Y, Chen J, Yang S, Gao F, Underhill CB, Creswell K, Zhang L (Sep 2003). "A peptide with three hyaluronan binding motifs inhibits tumor growth and induces apoptosis". Cancer Research 63 (18): 5685–90. PMID 14522884.
• Bekku Y, Su WD, Hirakawa S, Fässler R, Ohtsuka A, Kang JS, Sanders J, Murakami T, Ninomiya Y, Oohashi T (Sep 2003). "Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets". Molecular and Cellular Neurosciences 24 (1): 148–59. doi:10.1016/S1044-7431(03)00133-7. PMID 14550776.
• Dong Y, Han X, Xue Y, Dong B, Guo X, Hu G, Zhu C, Lu Y (Feb 2004). "Secreted brevican mRNA is expressed in the adult rat pituitary". Biochemical and Biophysical Research Communications 314 (3): 745–8. doi:10.1016/j.bbrc.2003.12.151. PMID 14741698.
• Viapiano MS, Bi WL, Piepmeier J, Hockfield S, Matthews RT (Aug 2005). "Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas". Cancer Research 65 (15): 6726–33. doi:10.1158/0008-5472.CAN-05-0585. PMID 16061654.
• Nakada M, Miyamori H, Kita D, Takahashi T, Yamashita J, Sato H, Miura R, Yamaguchi Y, Okada Y (Sep 2005). "Human glioblastomas overexpress ADAMTS-5 that degrades brevican". Acta Neuropathologica 110 (3): 239–46. doi:10.1007/s00401-005-1032-6. PMID 16133547.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.