Blood group B branched chain alpha-1,3-galactosidase

Heparanase
Identifiers
EC number 3.2.1.166
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Heparanase (EC 3.2.1.166, Hpa1 heparanase, Hpa1, heparanase 1, heparanase-1, C1A heparanase, HPSE) is an enzyme with systematic name heparan sulfate N-sulfo-D-glucosamine endoglucanase.[1][2][3][4][5][6][7][8][9] This enzyme catalyses the following chemical reaction

endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan

Heparanase cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group.

See also

References

  1. ↑ Bame, K.J. (2001). "Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans". Glycobiology 11 (6): 91R–98R. doi:10.1093/glycob/11.6.91r. PMID 11445547.
  2. ↑ Peterson, S.B. and Liu, J. (2010). "Unraveling the specificity of heparanase utilizing synthetic substrates". J. Biol. Chem. 285 (19): 14504–14513. doi:10.1074/jbc.M110.104166. PMID 20181948.
  3. ↑ Pikas, D.S., Li, J.P., Vlodavsky, I. and Lindahl, U. (1998). "Substrate specificity of heparanases from human hepatoma and platelets". J. Biol. Chem. 273: 18770–18777. doi:10.1074/jbc.273.30.18770. PMID 9668050.
  4. ↑ Okada, Y., Yamada, S., Toyoshima, M., Dong, J., Nakajima, M. and Sugahara, K. (2002). "Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence". J. Biol. Chem. 277 (45): 42488–42495. doi:10.1074/jbc.M206510200. PMID 12213822.
  5. ↑ Vreys, V. and David, G. (2007). "Mammalian heparanase: what is the message". J. Cell. Mol. Med. 11 (3): 427–452. doi:10.1111/j.1582-4934.2007.00039.x. PMID 17635638.
  6. ↑ Gong, F., Jemth, P., Escobar Galvis, M.L., Vlodavsky, I., Horner, A., Lindahl, U. and Li, J.P. (2003). "Processing of macromolecular heparin by heparanase". J. Biol. Chem. 278 (37): 35152–35158. doi:10.1074/jbc.M300925200. PMID 12837765.
  7. ↑ Toyoshima, M. and Nakajima, M. (1999). "Human heparanase. Purification, characterization, cloning, and expression". J. Biol. Chem. 274: 24153–24160. doi:10.1074/jbc.274.34.24153. PMID 10446189.
  8. ↑ Miao, H.Q., Navarro, E., Patel, S., Sargent, D., Koo, H., Wan, H., Plata, A., Zhou, Q., Ludwig, D., Bohlen, P. and Kussie, P. (2002). "Cloning, expression, and purification of mouse heparanase". Protein Expr. Purif. 26 (3): 425–431. doi:10.1016/s1046-5928(02)00558-2. PMID 12460766.
  9. ↑ Hammond, E., Li, C.P. and Ferro, V. (2010). "Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening". Anal. Biochem. 396 (1): 112–116. doi:10.1016/j.ab.2009.09.007. PMID 19748475.

External links

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