CENPC1

Centromere protein C
Identifiers
Symbols	CENPC ; CENP-C; CENPC1; MIF2; hcp-4
External IDs	OMIM: 117141 MGI: 99700 HomoloGene: 1371 GeneCards: CENPC Gene
Gene ontology Molecular function • DNA binding • centromeric DNA binding Cellular component • kinetochore • condensed chromosome kinetochore • condensed nuclear chromosome, centromeric region • nucleus • nucleoplasm • pericentric heterochromatin • cytoplasm • cytosol Biological process • mitotic cell cycle • nucleosome assembly • chromosome segregation • mitotic nuclear division • small GTPase mediated signal transduction • CENP-A containing nucleosome assembly • cell division • kinetochore assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1060	12617
Ensembl	ENSG00000145241	ENSMUSG00000029253
UniProt	Q03188	P49452
RefSeq (mRNA)	NM_001812	NM_007683
RefSeq (protein)	NP_001803	NP_031709
Location (UCSC)	Chr 4: 67.47 – 67.55 Mb	Chr 5: 86.01 – 86.07 Mb
PubMed search

Centromere protein C 1 is a protein that in humans is encoded by the CENPC1 gene.^[1][2]

Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.^[2]

References

1. McKay S, Thomson E, Cooke H (Dec 1994). "Sequence homologies and linkage group conservation of the human and mouse Cenpc genes". Genomics 22 (1): 36–40. doi:10.1006/geno.1994.1342. PMID 7959789.
2. "Entrez Gene: CENPC1 centromere protein C 1".

Further reading

• Saitoh H, Tomkiel J, Cooke CA; et al. (1992). "CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate.". Cell 70 (1): 115–25. doi:10.1016/0092-8674(92)90538-N. PMID 1339310.
• Pluta AF, Earnshaw WC (1996). "Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator.". J. Biol. Chem. 271 (31): 18767–74. doi:10.1074/jbc.271.31.18767. PMID 8702533.
• Xie Y, Heng HH (1996). "FISH mapping of centromere protein C (CENPC) on human chromosome 4q31→q21.". Cytogenet. Cell Genet. 74 (3): 192–3. doi:10.1159/000134412. PMID 8941372.
• Xie Y, Ni ZM, Gu JR; et al. (1997). "Human chromosome pellicle antibody recognizing centromere protein-C (CENP-C), the main component of the kinetochore.". Cell Res. 7 (1): 13–9. doi:10.1038/cr.1997.2. PMID 9261558.
• Pluta AF, Earnshaw WC, Goldberg IG (1998). "Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death.". J. Cell. Sci. 111. ( Pt 14): 2029–41. PMID 9645950.
• Song K, Gronemeyer B, Lu W; et al. (2002). "Mutational analysis of the central centromere targeting domain of human centromere protein C, (CENP-C).". Exp. Cell Res. 275 (1): 81–91. doi:10.1006/excr.2002.5495. PMID 11925107.
• Politi V, Perini G, Trazzi S; et al. (2002). "CENP-C binds the alpha-satellite DNA in vivo at specific centromere domains.". J. Cell. Sci. 115 (Pt 11): 2317–27. PMID 12006616.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Trazzi S, Bernardoni R, Diolaiti D; et al. (2003). "In vivo functional dissection of human inner kinetochore protein CENP-C.". J. Struct. Biol. 140 (1-3): 39–48. doi:10.1016/S1047-8477(02)00506-3. PMID 12490152.
• Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
• Suzuki N, Nakano M, Nozaki N; et al. (2004). "CENP-B interacts with CENP-C domains containing Mif2 regions responsible for centromere localization.". J. Biol. Chem. 279 (7): 5934–46. doi:10.1074/jbc.M306477200. PMID 14612452.
• Obuse C, Yang H, Nozaki N; et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.". Genes Cells 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096.
• Chung TL, Hsiao HH, Yeh YY; et al. (2004). "In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides.". J. Biol. Chem. 279 (38): 39653–62. doi:10.1074/jbc.M405637200. PMID 15272016.
• Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Foltz DR, Jansen LE, Black BE; et al. (2006). "The human CENP-A centromeric nucleosome-associated complex.". Nat. Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419.
• Izuta H, Ikeno M, Suzuki N; et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells.". Genes Cells 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Faragher AJ, Sun XM, Butterworth M; et al. (2007). "Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase.". Mol. Biol. Cell 18 (4): 1337–47. doi:10.1091/mbc.E06-05-0409. PMC 1838999. PMID 17287400.
• Wong LH, Brettingham-Moore KH, Chan L; et al. (2007). "Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere.". Genome Res. 17 (8): 1146–60. doi:10.1101/gr.6022807. PMC 1933521. PMID 17623812.