CENPI

Centromere protein I
Identifiers
Symbols	CENPI ; CENP-I; FSHPRH1; LRPR1; Mis6
External IDs	OMIM: 300065 MGI: 2147897 HomoloGene: 4899 GeneCards: CENPI Gene
Gene ontology Molecular function • protein binding Cellular component • kinetochore • nucleus • nucleoplasm • cytoplasm • cytosol Biological process • mitotic cell cycle • nucleosome assembly • small GTPase mediated signal transduction • sex differentiation • CENP-A containing nucleosome assembly • follicle-stimulating hormone signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2491	102920
Ensembl	ENSG00000102384	ENSMUSG00000031262
UniProt	Q92674	Q8K1K4
RefSeq (mRNA)	NM_006733	NM_001305631
RefSeq (protein)	NP_006724	NP_001292560
Location (UCSC)	Chr X: 101.1 – 101.16 Mb	Chr X: 134.31 – 134.36 Mb
PubMed search

Centromere protein I is a protein that in humans is encoded by the CENPI gene.^[1][2]

The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis.^[2]

References

1. Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420.
2. "Entrez Gene: CENPI centromere protein I".

Further reading

• Izuta H, Ikeno M, Suzuki N; et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells.". Genes Cells 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197.
• Foltz DR, Jansen LE, Black BE; et al. (2006). "The human CENP-A centromeric nucleosome-associated complex.". Nat. Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419.
• Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Ross MT, Grafham DV, Coffey AJ; et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Obuse C, Yang H, Nozaki N; et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.". Genes Cells 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096.
• Liu ST, Hittle JC, Jablonski SA; et al. (2003). "Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis.". Nat. Cell Biol. 5 (4): 341–5. doi:10.1038/ncb953. PMID 12640463.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Roberts RG, Kendall E, Vetrie D, Bobrow M (1997). "Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene.". Genomics 37 (1): 122–4. doi:10.1006/geno.1996.0528. PMID 8921378.
• Slegtenhorst-Eegdeman KE, Post M, Baarends WM; et al. (1995). "Regulation of gene expression in Sertoli cells by follicle-stimulating hormone (FSH): cloning and characterization of LRPR1, a primary response gene encoding a leucine-rich protein.". Mol. Cell. Endocrinol. 108 (1-2): 115–24. doi:10.1016/0303-7207(94)03468-9. PMID 7758824.
• Adams MD, Dubnick M, Kerlavage AR; et al. (1992). "Sequence identification of 2,375 human brain genes.". Nature 355 (6361): 632–4. doi:10.1038/355632a0. PMID 1538749.