TINF2

TERF1 (TRF1)-interacting nuclear factor 2
Rendering based on PDB 3BQO​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3BQO​, 3BU8​
Identifiers
Symbols	TINF2 ; DKCA3; TIN2
External IDs	OMIM: 604319 MGI: 107246 HomoloGene: 8264 GeneCards: TINF2 Gene
Gene ontology Molecular function • DNA binding • protein binding • telomeric DNA binding Cellular component • chromosome, telomeric region • nuclear telomere cap complex • nucleus • nucleoplasm • perinucleolar chromocenter • nuclear matrix • telosome Biological process • telomere maintenance • telomere maintenance via telomere lengthening • negative regulation of protein ADP-ribosylation • telomere assembly • positive regulation of telomere maintenance • negative regulation of telomere maintenance via telomerase • protein localization to chromosome • negative regulation of epithelial cell proliferation • protein localization to chromosome, telomeric region Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26277	28113
Ensembl	ENSG00000092330	ENSMUSG00000007589
UniProt	Q9BSI4	Q9QXG9
RefSeq (mRNA)	NM_001099274	NM_145705
RefSeq (protein)	NP_001092744	NP_663751
Location (UCSC)	Chr 14: 24.24 – 24.24 Mb	Chr 14: 55.68 – 55.68 Mb
PubMed search

TERF1-interacting nuclear factor 2 is a protein that in humans is encoded by the TINF2 gene.^[1][2] TIN2 is a component of the shelterin protein complex found at the end of telomeres.^[3]

Interactions

TINF2 has been shown to interact with ACD,^[4][5] POT1^[4][5][6] and TERF1.^[1][5][7]

References

1. Kim SH, Kaminker P, Campisi J (Dec 1999). "TIN2, a new regulator of telomere length in human cells". Nature Genetics 23 (4): 405–12. doi:10.1038/70508. PMID 10581025.
2. "Entrez Gene: TINF2 TERF1 (TRF1)-interacting nuclear factor 2".
3. Savage SA, Giri N, Baerlocher GM, Orr N, Lansdorp PM, Alter BP (Feb 2008). "TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita". American Journal of Human Genetics 82 (2): 501–9. doi:10.1016/j.ajhg.2007.10.004. PMC 2427222. PMID 18252230.
4. Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T (Jul 2004). "POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex". Genes & Development 18 (14): 1649–54. doi:10.1101/gad.1215404. PMC 478187. PMID 15231715.
5. Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z (Jul 2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nature Cell Biology 6 (7): 673–80. doi:10.1038/ncb1142. PMID 15181449.
6. Loayza D, De Lange T (Jun 2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature 423 (6943): 1013–8. doi:10.1038/nature01688. PMID 12768206.
7. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Li B, Oestreich S, de Lange T (May 2000). "Identification of human Rap1: implications for telomere evolution". Cell 101 (5): 471–83. doi:10.1016/S0092-8674(00)80858-2. PMID 10850490.
• Mignon-Ravix C, Depetris D, Delobel B, Croquette MF, Mattei MG (Feb 2002). "A human interstitial telomere associates in vivo with specific TRF2 and TIN2 proteins". European Journal of Human Genetics 10 (2): 107–12. doi:10.1038/sj.ejhg.5200775. PMID 11938440.
• Yamada M, Tsuji N, Nakamura M, Moriai R, Kobayashi D, Yagihashi A, Watanabe N (2003). "Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers". Anticancer Research 22 (6A): 3303–7. PMID 12530079.
• Loayza D, De Lange T (Jun 2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature 423 (6943): 1013–8. doi:10.1038/nature01688. PMID 12768206.
• Kim SH, Han S, You YH, Chen DJ, Campisi J (Jul 2003). "The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro". EMBO Reports 4 (7): 685–91. doi:10.1038/sj.embor.embor872. PMC 1326318. PMID 12835755.
• Loayza D, Parsons H, Donigian J, Hoke K, de Lange T (Mar 2004). "DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites". The Journal of Biological Chemistry 279 (13): 13241–8. doi:10.1074/jbc.M312309200. PMID 14715659.
• Ye JZ, de Lange T (Jun 2004). "TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex". Nature Genetics 36 (6): 618–23. doi:10.1038/ng1360. PMID 15133513.
• Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z (Jul 2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nature Cell Biology 6 (7): 673–80. doi:10.1038/ncb1142. PMID 15181449.
• Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T (Jul 2004). "POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex". Genes & Development 18 (14): 1649–54. doi:10.1101/gad.1215404. PMC 478187. PMID 15231715.
• Kim SH, Beausejour C, Davalos AR, Kaminker P, Heo SJ, Campisi J (Oct 2004). "TIN2 mediates functions of TRF2 at human telomeres". The Journal of Biological Chemistry 279 (42): 43799–804. doi:10.1074/jbc.M408650200. PMID 15292264.
• Ye JZ, Donigian JR, van Overbeek M, Loayza D, Luo Y, Krutchinsky AN, Chait BT, de Lange T (Nov 2004). "TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres". The Journal of Biological Chemistry 279 (45): 47264–71. doi:10.1074/jbc.M409047200. PMID 15316005.
• Liu D, O'Connor MS, Qin J, Songyang Z (Dec 2004). "Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins". The Journal of Biological Chemistry 279 (49): 51338–42. doi:10.1074/jbc.M409293200. PMID 15383534.
• Oh BK, Kim YJ, Park C, Park YN (Jan 2005). "Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis". The American Journal of Pathology 166 (1): 73–80. doi:10.1016/S0002-9440(10)62233-X. PMC 1602303. PMID 15632001.
• Kaminker P, Plachot C, Kim SH, Chung P, Crippen D, Petersen OW, Bissell MJ, Campisi J, Lelièvre SA (Mar 2005). "Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2". Journal of Cell Science 118 (Pt 6): 1321–30. doi:10.1242/jcs.01709. PMC 2933191. PMID 15741234.

External links

• GeneReviews/NCBI/NIH/UW entry on Dyskeratosis Congenita