CYP26C1

Cytochrome P450, family 26, subfamily C, polypeptide 1
Identifiers
Symbols	CYP26C1 ; FFDD4
External IDs	OMIM: 608428 MGI: 2679699 HomoloGene: 28089 IUPHAR: 1368 GeneCards: CYP26C1 Gene
EC number	1.14.-.-
Gene ontology Molecular function • retinoic acid binding • iron ion binding • retinoic acid 4-hydroxylase activity • heme binding Cellular component • endoplasmic reticulum membrane • integral component of membrane Biological process • vitamin metabolic process • xenobiotic metabolic process • central nervous system development • anterior/posterior pattern specification • neural crest cell development • retinoic acid catabolic process • small molecule metabolic process • organelle fusion • negative regulation of retinoic acid receptor signaling pathway • oxidation-reduction process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	340665	546726
Ensembl	ENSG00000187553	ENSMUSG00000062432
UniProt	Q6V0L0	B2RXA7
RefSeq (mRNA)	NM_183374	NM_001105201
RefSeq (protein)	NP_899230	NP_001098671
Location (UCSC)	Chr 10: 93.06 – 93.07 Mb	Chr 19: 37.69 – 37.69 Mb
PubMed search

CYP26C1 (cytochrome P450, family 26, subfamily c, polypeptide 1) is a protein which in humans is encoded by the CYP26C1 gene.^[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues.^[2]

CYP26C1 was found to show no expression in colorectal cancer cells or normal colonic epithelium.^[3]

References

1. Taimi M, Helvig C, Wisniewski J; et al. (January 2004). "A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid". J. Biol. Chem. 279 (1): 77–85. doi:10.1074/jbc.M308337200. PMID 14532297.
2. "Entrez Gene: CYP26C1".
3. Brown, Gordon; Beatriz Cash; Daniela Blihoghe; Petronella Johansson; Ayham Alnabulsi; Graeme Murray (2014-03-07). "The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer". PLOS ONE. doi:10.1371/journal.pone.0090776.

Further reading

• Deloukas P, Earthrowl ME, Grafham DV; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Rat E, Billaut-Laden I, Allorge D; et al. (2006). "Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida.". Birth Defects Res. Part a Clin. Mol. Teratol. 76 (6): 491–8. doi:10.1002/bdra.20275. PMID 16933217.
• Nelson DR, Zeldin DC, Hoffman SM; et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.". Pharmacogenetics 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
• Wan C, Shi Y, Zhao X; et al. (2009). "Positive association between ALDH1A2 and schizophrenia in the Chinese population.". Prog. Neuropsychopharmacol. Biol. Psychiatry 33 (8): 1491–5. doi:10.1016/j.pnpbp.2009.08.008. PMID 19703508.
• Grupe A, Li Y, Rowland C; et al. (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.