CYP3A7

Cytochrome P450, family 3, subfamily A, polypeptide 7
Identifiers
Symbols	CYP3A7 ; CP37; CYPIIIA7; P-450(HFL33); P-450111A7; P450-HFLA
External IDs	OMIM: 605340 HomoloGene: 133564 IUPHAR: 1339 GeneCards: CYP3A7 Gene
EC number	1.14.14.1
Gene ontology Molecular function • monooxygenase activity • iron ion binding • oxygen binding • heme binding • aromatase activity Cellular component • endoplasmic reticulum membrane Biological process • xenobiotic metabolic process • small molecule metabolic process • oxidation-reduction process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1551	13113
Ensembl	ENSG00000160870	ENSMUSG00000029727
UniProt	P24462	Q64464
RefSeq (mRNA)	NM_000765	NM_007819
RefSeq (protein)	NP_000756	NP_031845
Location (UCSC)	Chr 7: 99.71 – 99.74 Mb	Chr 5: 137.89 – 137.92 Mb
PubMed search

CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults.^[1] The gene location is 7q22.1.^[2]

The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals.^[3]

Notable alleles

The CYP3A7*1C allele is associated with poor outcomes in some cancer patients, possibly because of the effect of the enzyme on some chemotherapy agents.^[4]

References

1. Komori M, Nishio K, Ohi H, Kitada M, Kamataki T (February 1989). "Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450". J. Biochem. 105 (2): 161–3. PMID 2722762.
2. "Cytochrome P450, Subfamily IIIA, Polypeptide 7". OMIM. Retrieved March 14, 2013.
3. Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M (July 2000). "Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans". Pharmacogenetics 10 (5): 415–24. doi:10.1097/00008571-200007000-00005. PMID 10898111.
4. CYP3A7*1C Allele Associated With Poor Outcomes in CLL, Breast, and Lung Cancer

External links

• CYP3A7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)