CYP4A22

Cytochrome P450, family 4, subfamily A, polypeptide 22
Identifiers
Symbol CYP4A22
External IDs OMIM: 615341 MGI: 88612 HomoloGene: 134044 IUPHAR: 1342 GeneCards: CYP4A22 Gene
EC number 1.14.15.3
Orthologs
Species Human Mouse
Entrez 284541 13118
Ensembl ENSG00000162365 ENSMUSG00000078597
UniProt Q5TCH4 B0G0Y2
RefSeq (mRNA) NM_001010969 NM_172306
RefSeq (protein) NP_001010969 NP_758510
Location (UCSC) Chr 1:
47.14 – 47.15 Mb		 Chr 4:
115.41 – 115.44 Mb
PubMed search

CYP4A22 (cytochrome P450, family 4, subfamily A, polypeptide 22) also known as fatty acid omega-hydroxylase is a protein which in humans is encoded by the CYP4A22 gene.[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33.[2]

CYP4A22 was once considered, along with CYP4A11, CYP4F2, and CYP4F3, as active in metabolizing arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) by an omega oxidation reaction with the predominant 20-HETE-synthesizing enzymes in humans being CYP4F2 followed by CYP4A11; 20-HETE regulates blood flow, vascularization, blood pressure, and kidney tubule absorption of ions in rodents and possibly humans.[3] However, human CYP4A22 is expressed at very low levels in few tissues and may not be a functional enzyme in regard to the metabolism of arachidnoic acid to 20-HETE.[4][5]

References

  1. ↑ Hiratsuka M, Nozawa H, Katsumoto Y, Moteki T, Sasaki T, Konno Y, Mizugaki M (Jul 2006). "Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population". Mutation Research 599 (1-2): 98–104. doi:10.1016/j.mrfmmm.2006.02.008. PMID 16806293.
  2. ↑ "Entrez Gene: CYP4A22".
  3. ↑ Hoopes SL, Garcia V, Edin ML, Schwartzman ML, Zeldin DC (Jul 2015). "Vascular actions of 20-HETE". Prostaglandins & Other Lipid Mediators 120: 9–16. doi:10.1016/j.prostaglandins.2015.03.002. PMID 25813407.
  4. ↑ Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ, Brown NJ, Waterman MR, Capdevila JH (Jan 2005). "Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension". Circulation 111 (1): 63–9. doi:10.1161/01.CIR.0000151309.82473.59. PMID 15611369.
  5. ↑ Edson KZ, Rettie AE. "CYP4 enzymes as potential drug targets: focus on enzyme multiplicity, inducers and inhibitors, and therapeutic modulation of 20-hydroxyeicosatetraenoic acid (20-HETE) synthase and fatty acid ω-hydroxylase activities". Current Topics in Medicinal Chemistry 13 (12): 1429–40. doi:10.2174/15680266113139990110. PMID 23688133.

Further reading

  • Bellamine A, Wang Y, Waterman MR, Gainer JV, Dawson EP, Brown NJ, Capdevila JH (Jan 2003). "Characterization of the CYP4A11 gene, a second CYP4A gene in humans". Archives of Biochemistry and Biophysics 409 (1): 221–7. doi:10.1016/S0003-9861(02)00545-3. PMID 12464262. 
  • Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ, Brown NJ, Waterman MR, Capdevila JH (Jan 2005). "Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension". Circulation 111 (1): 63–9. doi:10.1161/01.CIR.0000151309.82473.59. PMID 15611369. 
  • Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (Jan 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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