CYP2W1

Cytochrome P450, family 2, subfamily W, polypeptide 1
Identifiers
Symbols	CYP2W1 ; MGC34287
External IDs	OMIM: 615967 MGI: 3616076 HomoloGene: 69239 IUPHAR: 1336 GeneCards: CYP2W1 Gene
EC number	1.14.14.-
Gene ontology Molecular function • iron ion binding • steroid hydroxylase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • oxygen binding • heme binding Cellular component • cytoplasm • endoplasmic reticulum lumen • endoplasmic reticulum membrane • plasma membrane • cell surface • intracellular membrane-bounded organelle Biological process • organic acid metabolic process • xenobiotic metabolic process • exogenous drug catabolic process • aflatoxin B1 metabolic process • small molecule metabolic process • oxidation-reduction process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54905	545817
Ensembl	ENSG00000073067	ENSMUSG00000029541
UniProt	Q8TAV3	E9Q816
RefSeq (mRNA)	NM_017781	NM_001160265
RefSeq (protein)	NP_060251	NP_001153737
Location (UCSC)	Chr 7: 0.98 – 0.99 Mb	Chr 5: 139.35 – 139.36 Mb
PubMed search

CYP2W1 (cytochrome P450, family 2, subfamily W, polypeptide 1) is a protein that in humans is encoded by the CYP2W1 gene.^[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.^[2] CYP2W1 is an interesting enzyme since it is mainly expressed in tumors and not in normal human tissue.

References

1. Gerhard DS, Wagner L, Feingold EA; et al. (October 2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
2. "Entrez Gene: CYP2W1".

Further reading

• Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hanzawa Y, Sasaki T, Mizugaki M; et al. (2008). "Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population". Drug Metab. Dispos. 36 (2): 349–52. doi:10.1124/dmd.107.019141. PMID 17998294.
• Yoshioka H, Kasai N, Ikushiro S; et al. (2006). "Enzymatic properties of human CYP2W1 expressed in Escherichia coli". Biochem. Biophys. Res. Commun. 345 (1): 169–74. doi:10.1016/j.bbrc.2006.04.080. PMID 16677611.
• Karlgren M, Gomez A, Stark K; et al. (2006). "Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1". Biochem. Biophys. Res. Commun. 341 (2): 451–8. doi:10.1016/j.bbrc.2005.12.200. PMID 16426568.
• Gomez A, Karlgren M, Edler D; et al. (2007). "Expression of CYP2W1 in colon tumors: regulation by gene methylation". Pharmacogenomics 8 (10): 1315–25. doi:10.2217/14622416.8.10.1315. PMID 17979506.
• Nelson DR, Zeldin DC, Hoffman SM; et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.