Deoxyribonuclease II
deoxyribonuclease II alpha | |
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Identifiers | |
Symbol | DNASE2 |
Alt. symbols | DNASE2A, DRN2, DNL, DNL2 |
Entrez | 1777 |
HUGO | 2960 |
OMIM | 126350 |
RefSeq | NM_001375 |
UniProt | O00115 |
Other data | |
EC number | 3.1.22.1 |
Locus | Chr. 19 p13.2 |
deoxyribonuclease II beta | |
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Identifiers | |
Symbol | DNASE2B |
Entrez | 58511 |
HUGO | 28875 |
OMIM | 608057 |
RefSeq | NM_021233 |
UniProt | Q8WZ79 |
Other data | |
EC number | 3.1.22.1 |
Locus | Chr. 1 p22.3 |
Deoxyribonuclease II (EC 3.1.22.1, DNase II, pancreatic DNase II, deoxyribonucleate 3'-nucleotidohydrolase, pancreatic DNase II, acid deoxyribonuclease, acid DNase) hydrolyzes deoxyribonucleotide linkages in native and denatured DNA, yielding products with 3'-phosphates. As the name implies, it is more effective at acid pH.
There are several known DNases II, including:
- DNase II alpha (usually just called DNase II)
- DNase II beta (also called DLAD, or DNase II-Like Acid DNase)
External links
- deoxyribonuclease II at the US National Library of Medicine Medical Subject Headings (MeSH)
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