EIF2B1

Eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3ECS​
Identifiers
Symbols	EIF2B1 ; EIF2B; EIF2BA
External IDs	OMIM: 606686 MGI: 2384802 HomoloGene: 1080 GeneCards: EIF2B1 Gene
Gene ontology Molecular function • translation initiation factor activity • guanyl-nucleotide exchange factor activity • protein binding • GTP binding • GDP binding • enzyme regulator activity • S-methyl-5-thioribose-1-phosphate isomerase activity Cellular component • cytoplasm • cytosol • eukaryotic translation initiation factor 2B complex • plasma membrane • membrane Biological process • translation • translational initiation • regulation of translational initiation • response to heat • response to glucose • gene expression • oligodendrocyte development • L-methionine biosynthetic process from methylthioadenosine • negative regulation of translational initiation in response to stress • response to peptide hormone • positive regulation of GTPase activity • cellular protein metabolic process • cellular response to stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1967	209354
Ensembl	ENSG00000111361	ENSMUSG00000029388
UniProt	Q14232	Q99LC8
RefSeq (mRNA)	NM_001414	NM_145371
RefSeq (protein)	NP_001405	NP_663346
Location (UCSC)	Chr 12: 123.62 – 123.63 Mb	Chr 5: 124.57 – 124.58 Mb
PubMed search

Translation initiation factor eIF-2B subunit alpha is a protein that in humans is encoded by the EIF2B1 gene.^[1]

Interactions

EIF2B1 has been shown to interact with EIF2B5.^[2][3]

References

1. "Entrez Gene: EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa".
2. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
3. Anthony TG, Fabian JR, Kimball SR, Jefferson LS (June 2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID 10858531.

Further reading

• Hershey JW (1991). "Translational control in mammalian cells". Annu. Rev. Biochem. 60: 717–55. doi:10.1146/annurev.bi.60.070191.003441. PMID 1883206.
• Flowers KM, Mellor H, Kimball SR, Jefferson LS (1996). "Structure and sequence of the gene encoding the alpha-subunit of rat translation initiation factor-2B". Biochim. Biophys. Acta 1264 (2): 163–7. doi:10.1016/0167-4781(95)00160-i. PMID 7495858.
• Welsh GI, Miyamoto S, Price NT, Safer B, Proud CG (1996). "T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3". J. Biol. Chem. 271 (19): 11410–3. doi:10.1074/jbc.271.19.11410. PMID 8626696.
• Yang W, Hinnebusch AG (1996). "Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2". Mol. Cell. Biol. 16 (11): 6603–16. PMC 231662. PMID 8887689.
• Klein U, Ramirez MT, Kobilka BK, von Zastrow M (1997). "A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B". J. Biol. Chem. 272 (31): 19099–102. doi:10.1074/jbc.272.31.19099. PMID 9235896.
• Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS (1998). "Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B". J. Biol. Chem. 273 (5): 3039–44. doi:10.1074/jbc.273.5.3039. PMID 9446619.
• Gomez E, Pavitt GD (2000). "Identification of Domains and Residues within the ɛ Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2Bɛ) Required for Guanine Nucleotide Exchange Reveals a Novel Activation Function Promoted by eIF2B Complex Formation". Mol. Cell. Biol. 20 (11): 3965–76. doi:10.1128/MCB.20.11.3965-3976.2000. PMC 85753. PMID 10805739.
• Anthony TG, Fabian JR, Kimball SR, Jefferson LS (2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID 10858531.
• Williams DD, Price NT, Loughlin AJ, Proud CG (2001). "Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein". J. Biol. Chem. 276 (27): 24697–703. doi:10.1074/jbc.M011788200. PMID 11323413.
• van der Knaap MS, Leegwater PA, Könst AA, Visser A, Naidu S, Oudejans CB, Schutgens RB, Pronk JC (2002). "Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter". Ann. Neurol. 51 (2): 264–70. doi:10.1002/ana.10112. PMID 11835386.
• Fogli A, Dionisi-Vici C, Deodato F, Bartuli A, Boespflug-Tanguy O, Bertini E (2003). "A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation". Neurology 59 (12): 1966–8. doi:10.1212/01.wnl.0000041666.76863.47. PMID 12499492.
• Fogli A, Rodriguez D, Eymard-Pierre E, Bouhour F, Labauge P, Meaney BF, Zeesman S, Kaneski CR, Schiffmann R, Boespflug-Tanguy O (2003). "Ovarian Failure Related to Eukaryotic Initiation Factor 2B Mutations". Am. J. Hum. Genet. 72 (6): 1544–50. doi:10.1086/375404. PMC 1180314. PMID 12707859.
• van der Knaap MS, van Berkel CG, Herms J, van Coster R, Baethmann M, Naidu S, Boltshauser E, Willemsen MA, Plecko B, Hoffmann GF, Proud CG, Scheper GC, Pronk JC (2004). "eIF2B-Related Disorders: Antenatal Onset and Involvement of Multiple Organs". Am. J. Hum. Genet. 73 (5): 1199–207. doi:10.1086/379524. PMC 1180499. PMID 14566705.
• Richardson JP, Mohammad SS, Pavitt GD (2004). "Mutations Causing Childhood Ataxia with Central Nervous System Hypomyelination Reduce Eukaryotic Initiation Factor 2B Complex Formation and Activity". Mol. Cell. Biol. 24 (6): 2352–63. doi:10.1128/MCB.24.6.2352-2363.2004. PMC 355856. PMID 14993275.
• Li W, Wang X, Van Der Knaap MS, Proud CG (2004). "Mutations Linked to Leukoencephalopathy with Vanishing White Matter Impair the Function of the Eukaryotic Initiation Factor 2B Complex in Diverse Ways". Mol. Cell. Biol. 24 (8): 3295–306. doi:10.1128/MCB.24.8.3295-3306.2004. PMC 381664. PMID 15060152.
• Van Haren K, van der Voorn JP, Peterson DR, van der Knaap MS, Powers JM (2004). "The life and death of oligodendrocytes in vanishing white matter disease". J. Neuropathol. Exp. Neurol. 63 (6): 618–30. PMID 15217090.
• Yin X, Warner DR, Roberts EA, Pisano MM, Greene RM (2005). "Identification of novel CBP interacting proteins in embryonic orofacial tissue". Biochem. Biophys. Res. Commun. 329 (3): 1010–7. doi:10.1016/j.bbrc.2005.02.075. PMID 15752756.