EIF3K

Eukaryotic translation initiation factor 3, subunit K
PDB rendering based on 1rz4.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1RZ4​, 3J8B​, 3J8C​
Identifiers
Symbols	EIF3K ; ARG134; EIF3-p28; EIF3S12; HSPC029; M9; MSTP001; PLAC-24; PLAC24; PRO1474; PTD001
External IDs	OMIM: 609596 MGI: 1921080 HomoloGene: 8292 GeneCards: EIF3K Gene
Gene ontology Molecular function • translation initiation factor activity • protein binding • ribosome binding Cellular component • nucleus • cytoplasm • cytosol • eukaryotic translation initiation factor 3 complex • membrane • eukaryotic 43S preinitiation complex • eukaryotic 48S preinitiation complex • extracellular exosome Biological process • formation of translation preinitiation complex • translation • translational initiation • regulation of translational initiation • gene expression • cellular protein metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27335	73830
Ensembl	ENSG00000178982	ENSMUSG00000053565
UniProt	Q9UBQ5	Q9DBZ5
RefSeq (mRNA)	NM_001300992	NM_001285942
RefSeq (protein)	NP_001287921	NP_001272871
Location (UCSC)	Chr 19: 38.62 – 38.64 Mb	Chr 7: 28.97 – 28.98 Mb
PubMed search

Eukaryotic translation initiation factor 3 subunit K is a protein that in humans is encoded by the EIF3K gene.^[1][2][3]

Function

The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003).[supplied by OMIM]^[3]

Interactions

EIF3K has been shown to interact with Cyclin D3^[4] and EIF3A.^[2][5]

See also

• Eukaryotic initiation factor 3 (eIF3)

References

1. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
2. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (Oct 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.
3. "Entrez Gene: EIF3S12 eukaryotic translation initiation factor 3, subunit 12".
4. Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, Gu J (Aug 2004). "Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3". FEBS Lett. 573 (1-3): 139–46. doi:10.1016/j.febslet.2004.07.071. PMID 15327989.
5. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

• Karki S, Ligon LA, DeSantis J, Tokito M, Holzbaur EL (2002). "PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact". Mol. Biol. Cell 13 (5): 1722–34. doi:10.1091/mbc.02-02-0011. PMC 111139. PMID 12006665.
• Wei Z, Zhang P, Zhou Z, Cheng Z, Wan M, Gong W (2004). "Crystal structure of human eIF3k, the first structure of eIF3 subunits". J. Biol. Chem. 279 (33): 34983–90. doi:10.1074/jbc.M405158200. PMID 15180986.
• Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, Gu J (2004). "Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3". FEBS Lett. 573 (1-3): 139–46. doi:10.1016/j.febslet.2004.07.071. PMID 15327989.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.