Guanosine nucleotide dissociation inhibitor
| GDP dissociation inhibitor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | GDI | ||||||||
| Pfam | PF00996 | ||||||||
| InterPro | IPR002005 | ||||||||
| SCOP | 1gnd | ||||||||
| SUPERFAMILY | 1gnd | ||||||||
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A guanosine nucleotide dissociation inhibitor (GDI) binds to the GDP-bound form of Rho and Rab small GTPases and not only prevents exchange (maintaining the small GTPase in an off-state), but also prevents the small GTPase from localizing at the membrane, which is their place of action. This inhibition can be removed by the action of a GDI displacement factor.[1] It also inhibits cdc42 by binding to its tail and preventing its insertion into membranes; hence it cannot trigger WASPs and cannot lead to nucleation of F-actin.
References
- ↑ Dirac-Svejstrup, A B. "Identification of a GDI displacement factor that releases endosomal Rab GTPases from Rab-GDI.". The EMBO Journal. Retrieved 31 January 2013.
External links
- Guanine Nucleotide Dissociation Inhibitors at the US National Library of Medicine Medical Subject Headings (MeSH)
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