Kappa-carrageenase

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Kappa-carrageenase (EC 3.2.1.83, kappa-carrageenan 4-beta-D-glycanohydrolase) is an enzyme with systematic name kappa-carrageenan 4-beta-D-glycanohydrolase (configuration-retaining).^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

Endohydrolysis of (1->4)-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans

The main products of hydrolysis are neocarrabiose-sulfate and neocarratetraose-sulfate.

References

↑ Weigl, J. and Yashe, W. (1966). "The enzymic hydrolysis of carrageenan by Pseudomonas carrageenovora: purification of a κ-carrageenase". Can. J. Microbiol. 12: 939–947. doi:10.1139/m66-127. PMID 5972647.
↑ Potin, P., Sanseau, A., Le Gall, Y., Rochas, C. and Kloareg, B. (1991). "Purification and characterization of a new κ-carrageenase from a marine Cytophaga-like bacterium". Eur. J. Biochem. 201: 241–247. doi:10.1111/j.1432-1033.1991.tb16280.x. PMID 1915370.
↑ Potin, P., Richard, C., Barbeyron, T., Henrissat, B., Gey, C., Petillot, Y., Forest, E., Dideberg, O., Rochas, C. and Kloareg, B. (1995). "Processing and hydrolytic mechanism of the cgkA-encoded κ-carrageenase of Alteromonas carrageenovora". Eur. J. Biochem. 228: 971–975. doi:10.1111/j.1432-1033.1995.tb20348.x. PMID 7737202.
↑ Michel, G., Barbeyron, T., Flament, D., Vernet, T., Kloareg, B. and Dideberg, O. (1999). "Expression, purification, crystallization and preliminary x-ray analysis of the κ-carrageenase from Pseudoalteromonas carrageenovora". Acta Crystallogr. D Biol. Crystallogr. 55: 918–920. doi:10.1107/s0907444998018526. PMID 10089334.
↑ Michel, G., Chantalat, L., Duee, E., Barbeyron, T., Henrissat, B., Kloareg, B. and Dideberg, O. (2001). "The κ-carrageenase of P. carrageenovora features a tunnel-shaped active site: a novel insight in the evolution of Clan-B glycoside hydrolases". Structure 9: 513–525. doi:10.1016/s0969-2126(01)00612-8. PMID 11435116.

External links

Kappa-carrageenase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: sugar hydrolases (EC 3.2)

3.2.1: Glycoside hydrolases

Disaccharidase	Sucrase/Sucrase-isomaltase/Invertase Maltase Trehalase Lactase

Glucosidases	Cellulase Alpha-glucosidase Acid Neutral AB Neutral C Beta-glucosidase cytosolic Debranching enzyme

Other	Amylase Alpha-amylase Chitinase Lysozyme Neuraminidase NEU1 NEU2 NEU3 NEU4 Bacterial neuraminidase Viral neuraminidase Galactosidases Alpha Beta alpha-Mannosidase Glucuronidase Hyaluronidase Pullulanase Glucosylceramidase lysosomal non-lysosomal Galactosylceramidase Alpha-N-acetylgalactosaminidase NAGA Alpha-N-acetylglucosaminidase Fucosidase Hexosaminidase HEXA HEXB Iduronidase Maltase-glucoamylase Heparanase HPSE2

3.2.2: Hydrolysing
N-Glycosyl compounds

DNA glycosylases: Oxoguanine glycosylase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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