Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

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Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (EC 3.2.1.114, mannosidase II, exo-1,3-1,6-alpha-mannosidase, alpha-D-mannosidase II, alpha-mannosidase II, alpha1-3,6-mannosidase, GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase, Golgi alpha-mannosidase II, ManII, 1,3(1,6)-alpha-D-mannosidase, 1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase) is an enzyme with systematic name (1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

Hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man5(GlcNAc)3

This enzyme is involved in the synthesis of glycoproteins.

References

↑ Harpaz N, Schachter H (May 1980). "Control of glycoprotein synthesis. Processing of asparagine-linked oligosaccharides by one or more rat liver Golgi alpha-D-mannosidases dependent on the prior action of UDP-N-acetylglucosamine: alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase I". The Journal of Biological Chemistry 255 (10): 4894–902. PMID 6445359.
↑ Tulsiani DR, Hubbard SC, Robbins PW, Touster O (Apr 1982). "alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates". The Journal of Biological Chemistry 257 (7): 3660–8. PMID 7061502.
↑ Tulsiani DR, Opheim DJ, Touster O (May 1977). "Purification and characterization of alpha-D-mannosidase from rat liver golgi membranes". The Journal of Biological Chemistry 252 (10): 3227–33. PMID 863880.
↑ Athanasopoulos VI, Niranjan K, Rastall RA (Mar 2005). "The production, purification and characterisation of two novel alpha-D-mannosidases from Aspergillus phoenicis". Carbohydrate Research 340 (4): 609–17. doi:10.1016/j.carres.2005.01.005. PMID 15721331.

External links

Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: sugar hydrolases (EC 3.2)

3.2.1: Glycoside hydrolases

Disaccharidase	Sucrase/Sucrase-isomaltase/Invertase Maltase Trehalase Lactase

Glucosidases	Cellulase Alpha-glucosidase Acid Neutral AB Neutral C Beta-glucosidase cytosolic Debranching enzyme

Other	Amylase Alpha-amylase Chitinase Lysozyme Neuraminidase NEU1 NEU2 NEU3 NEU4 Bacterial neuraminidase Viral neuraminidase Galactosidases Alpha Beta alpha-Mannosidase Glucuronidase Hyaluronidase Pullulanase Glucosylceramidase lysosomal non-lysosomal Galactosylceramidase Alpha-N-acetylgalactosaminidase NAGA Alpha-N-acetylglucosaminidase Fucosidase Hexosaminidase HEXA HEXB Iduronidase Maltase-glucoamylase Heparanase HPSE2

3.2.2: Hydrolysing
N-Glycosyl compounds

DNA glycosylases: Oxoguanine glycosylase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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