Mannosyl-oligosaccharide 1,2-alpha-mannosidase

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Mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113, mannosidase 1A, mannosidase 1B, 1,2-alpha-mannosidase, exo-alpha-1,2-mannanase, mannose-9 processing alpha-mannosidase, glycoprotein processing mannosidase I, mannosidase I, Man9-mannosidase, ManI, 1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase) is an enzyme with systematic name 2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase.^[1]^[2] This enzyme catalyses the following chemical reaction

Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2

This enzyme is involved in the synthesis of glycoproteins.

Kifunensine is a potent inhibitor of mannosidase I.

References

↑ Tabas, I. and Kornfeld, S. (1979). "Purification and characterization of a rat liver Golgi α-mannosidase capable of processing asparagine-linked oligosaccharides". J. Biol. Chem. 254: 11655–11663. PMID 500665.
↑ Tulsiani, D.R.P; Hubbard, S.C.; Robbins, P.W.; Touster, O. (1982). "α-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN₅-cleaving enzyme in glycoprotein biosynthesis and mannosidases IA and IB are the enzymes converting Man₉ precursors to Man₅ intermediates". J. Biol. Chem. 257: 3660–3668. PMID 7061502.

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Mannosyl-oligosaccharide 1,2-alpha-mannosidase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: sugar hydrolases (EC 3.2)

3.2.1: Glycoside hydrolases

Disaccharidase	Sucrase/Sucrase-isomaltase/Invertase Maltase Trehalase Lactase

Glucosidases	Cellulase Alpha-glucosidase Acid Neutral AB Neutral C Beta-glucosidase cytosolic Debranching enzyme

Other	Amylase Alpha-amylase Chitinase Lysozyme Neuraminidase NEU1 NEU2 NEU3 NEU4 Bacterial neuraminidase Viral neuraminidase Galactosidases Alpha Beta alpha-Mannosidase Glucuronidase Hyaluronidase Pullulanase Glucosylceramidase lysosomal non-lysosomal Galactosylceramidase Alpha-N-acetylgalactosaminidase NAGA Alpha-N-acetylglucosaminidase Fucosidase Hexosaminidase HEXA HEXB Iduronidase Maltase-glucoamylase Heparanase HPSE2

3.2.2: Hydrolysing
N-Glycosyl compounds

DNA glycosylases: Oxoguanine glycosylase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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