NAD(P)+ nucleosidase

NAD(P)+ nucleosidase
Identifiers
EC number	3.2.2.6
CAS number	9025-46-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a NAD(P)+ nucleosidase (EC 3.2.2.6) is an enzyme that catalyzes the chemical reaction

NAD(P)+ + H₂O $\rightleftharpoons$ ADP-ribose(P) + nicotinamide

The 3 substrates of this enzyme are NAD⁺, NADP⁺, and H₂O, whereas its two products are ADP-ribose and nicotinamide.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is NAD(P)+ glycohydrolase. Other names in common use include nicotinamide adenine dinucleotide (phosphate) nucleosidase, triphosphopyridine nucleotidase, NAD(P) nucleosidase, NAD(P)ase, and nicotinamide adenine dinucleotide (phosphate) glycohydrolase. This enzyme participates in nicotinate and nicotinamide metabolism.

References

• ALIVISATOS SG, WOOLLEY DW (1956). "Solubilization and purification of the diphosphopyridine nucleotidase from beef spleen". J. Biol. Chem. 219 (2): 823–32. PMID 13319302.
• ZATMAN LJ, KAPLAN NO, COLOWICK SP (1953). "Inhibition of spleen diphosphopyridine nucleotidase by nicotinamide, an exchange reaction". J. Biol. Chem. 200 (1): 197–212. PMID 13034774.
• Zatman LJ, Kaplan NO, Colowick SP and Ciotti MM (1953). "Formation of the isonicotinic acid hydrazide analog of DPN". J. Am. Chem. Soc. 75 (13): 3293–3294. doi:10.1021/ja01109a527.