NAIP (gene)

NLR family, apoptosis inhibitory protein
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2VM5​
Identifiers
Symbols	NAIP ; BIRC1; NLRB1; psiNAIP
External IDs	OMIM: 600355 MGI: 1298223 HomoloGene: 136092 GeneCards: NAIP Gene
Gene ontology Molecular function • ubiquitin-protein transferase activity • protein binding • ATP binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • metal ion binding Cellular component • nucleus • cytoplasm • spindle microtubule • basolateral plasma membrane • neuron projection • perikaryon • extracellular exosome Biological process • inflammatory response • nervous system development • regulation of signal transduction • protein ubiquitination • negative regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to amino acid • negative regulation of neuron apoptotic process • innate immune response • response to axon injury • mitotic spindle assembly • inhibition of cysteine-type endopeptidase activity involved in apoptotic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4671	17948
Ensembl	ENSG00000249437	ENSMUSG00000078945
UniProt	Q13075	Q9QUK4
RefSeq (mRNA)	NM_004536	NM_001126182
RefSeq (protein)	NP_004527	NP_001119654
Location (UCSC)	Chr 5: 70.97 – 71.03 Mb	Chr 13: 100.14 – 100.2 Mb
PubMed search

Baculoviral IAP repeat-containing protein 1 is a protein that in humans is encoded by the NAIP gene.^[1][2]

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1.

The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[2]

References

1. Roy N, Mahadevan MS, McLean M, Shutler G, Yaraghi Z, Farahani R, Baird S, Besner-Johnston A, Lefebvre C, Kang X; et al. (Feb 1995). "The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy". Cell 80 (1): 167–78. doi:10.1016/0092-8674(95)90461-1. PMID 7813013.
2. "Entrez Gene: NAIP NLR family, apoptosis inhibitory protein".

Further reading

• van der Steege G, Draaijers TG, Grootscholten PM, et al. (1995). "A provisional transcript map of the spinal muscular atrophy (SMA) critical region.". Eur. J. Hum. Genet. 3 (2): 87–95. PMID 7552146.
• Liston P, Roy N, Tamai K, et al. (1996). "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.". Nature 379 (6563): 349–53. doi:10.1038/379349a0. PMID 8552191.
• Chen Q, Baird SD, Mahadevan M, et al. (1998). "Sequence of a 131-kb region of 5q13.1 containing the spinal muscular atrophy candidate genes SMN and NAIP.". Genomics 48 (1): 121–7. doi:10.1006/geno.1997.5141. PMID 9503025.
• Monani UR, Lorson CL, Parsons DW, et al. (1999). "A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2.". Hum. Mol. Genet. 8 (7): 1177–83. doi:10.1093/hmg/8.7.1177. PMID 10369862.
• Yamamoto K, Sakai H, Hadano S, et al. (1999). "Identification of two distinct transcripts for the neuronal apoptosis inhibitory protein gene.". Biochem. Biophys. Res. Commun. 264 (3): 998–1006. doi:10.1006/bbrc.1999.1615. PMID 10544044.
• Mercer EA, Korhonen L, Skoglösa Y, et al. (2000). "NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways.". EMBO J. 19 (14): 3597–607. doi:10.1093/emboj/19.14.3597. PMC 313967. PMID 10899114.
• Sanna MG, da Silva Correia J, Ducrey O, et al. (2002). "IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition.". Mol. Cell. Biol. 22 (6): 1754–66. doi:10.1128/MCB.22.6.1754-1766.2002. PMC 135597. PMID 11865055.
• Akutsu T, Nishio H, Sumino K, et al. (2002). "Molecular genetics of spinal muscular atrophy: contribution of the NAIP gene to clinical severity.". Kobe Journal of Medical Sciences 48 (1-2): 25–31. PMID 11912351.
• Xu M, Okada T, Sakai H, et al. (2002). "Functional human NAIP promoter transcription regulatory elements for the NAIP and PsiNAIP genes.". Biochim. Biophys. Acta 1574 (1): 35–50. doi:10.1016/S0167-4781(01)00343-8. PMID 11955612.
• Notarbartolo M, Cervello M, Dusonchet L, D'Alessandro N (2002). "NAIP-deltaEx10-11: a novel splice variant of the apoptosis inhibitor NAIP differently expressed in drug-sensitive and multidrug-resistant HL60 leukemia cells.". Leuk. Res. 26 (9): 857–62. doi:10.1016/S0145-2126(02)00016-4. PMID 12127562.
• Lindholm D, Mercer EA, Yu LY, et al. (2002). "Neuronal apoptosis inhibitory protein: Structural requirements for hippocalcin binding and effects on survival of NGF-dependent sympathetic neurons.". Biochim. Biophys. Acta 1600 (1-2): 138–47. doi:10.1016/S1570-9639(02)00454-5. PMID 12445469.
• Damiano JS, Oliveira V, Welsh K, Reed JC (2004). "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses.". Biochem. J. 381 (Pt 1): 213–9. doi:10.1042/BJ20031506. PMC 1133779. PMID 15107016.
• Davoodi J, Lin L, Kelly J, et al. (2004). "Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9.". J. Biol. Chem. 279 (39): 40622–8. doi:10.1074/jbc.M405963200. PMID 15280366.
• Aubin D, Gagnon A, Grunder L, et al. (2004). "Adipogenic and antiapoptotic protein levels in human adipose stromal cells after weight loss.". Obes. Res. 12 (8): 1231–4. doi:10.1038/oby.2004.156. PMID 15340105.
• Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5.". Nature 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
• Romanish MT, Lock WM, van de Lagemaat LN, et al. (2007). "Repeated recruitment of LTR retrotransposons as promoters by the anti-apoptotic locus NAIP during mammalian evolution.". PLoS Genet. 3 (1): e10. doi:10.1371/journal.pgen.0030010. PMC 1781489. PMID 17222062.
• Maier JK, Balabanian S, Coffill CR, et al. (2007). "Distribution of neuronal apoptosis inhibitory protein in human tissues.". J. Histochem. Cytochem. 55 (9): 911–23. doi:10.1369/jhc.6A7144.2007. PMID 17510375.

External links

• Neuronal Apoptosis-Inhibitory Protein at the US National Library of Medicine Medical Subject Headings (MeSH)