Protein-glucosylgalactosylhydroxylysine glucosidase

protein-glucosylgalactosylhydroxylysine glucosidase
Identifiers
EC number	3.2.1.107
CAS number	72829-45-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a protein-glucosylgalactosylhydroxylysine glucosidase (EC 3.2.1.107) is an enzyme that catalyzes the chemical reaction

protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine + H₂O $\rightleftharpoons$ D-glucose + protein beta-D-galactosyl-L-hydroxylysine

Thus, the two substrates of this enzyme are protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine and H₂O, whereas its two products are D-glucose and protein beta-D-galactosyl-L-hydroxylysine.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase. Other names in common use include 2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-, and lysine glucohydrolase.

References

• Hamazaki H, Hotta K (1979). "Purification and characterization of an alpha-glucosidase specific for hydroxylysine-linked disaccharide of collagen". J. Biol. Chem. 254 (19): 9682–7. PMID 385589.
• Hamazaki H, Hotta K (1980). "Enzymatic hydrolysis of disaccharide unit of collagen. Isolation of 2-O-alpha-D-glucopyranosyl-O-beta-D-galactopyranosyl-hydroxylysine glucohydrolase from rat spleens". Eur. J. Biochem. 111 (2): 587–91. doi:10.1111/j.1432-1033.1980.tb04975.x. PMID 7460918.
• Sternberg M, Spiro RG (1979). "Studies on the catabolism of the hydroxylysine-linked disaccharide units of basement membranes and collagens. Isolation and characterization of a rat kidney alpha-glucosidase of high specificity". J. Biol. Chem. 254 (20): 10329–36. PMID 385599.