Pyrimidine-5'-nucleotide nucleosidase

pyrimidine-5'-nucleotide nucleosidase
Identifiers
EC number	3.2.2.10
CAS number	9023-31-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a pyrimidine-5'-nucleotide nucleosidase (EC 3.2.2.10) is an enzyme that catalyzes the chemical reaction

a pyrimidine 5'-nucleotide + H₂O $\rightleftharpoons$ D-ribose 5-phosphate + a pyrimidine base

Thus, the two substrates of this enzyme are pyrimidine 5'-nucleotide and H₂O, whereas its two products are D-ribose 5-phosphate and pyrimidine base.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase. Other names in common use include pyrimidine nucleotide N-ribosidase, and Pyr5N. This enzyme participates in pyrimidine metabolism.

References

• Imada A (1967). "Degradation of pyrimidine nucleotides by enzyme systems of Streptomyces. II. Pyrimidine 5'-nucleotide phosphoribo(deoxyribo) hydrolase of Streptomyces virginiae". J. Gen. Appl. Microbiol. 13 (3): 267–278. doi:10.2323/jgam.13.267.
• Imada A, Kuno M and Igarasi S (1967). "Degradation of pyrimidine nucleotides by enzyme systems of Streptomyces. I. Ribose-5-phosphate formation from pyrimidine nucleotides". J. Gen. Appl. Microbiol. 13: 255–265. doi:10.2323/jgam.13.255.