Uteroglobin

Secretoglobin, family 1A, member 1 (uteroglobin)
Identifiers
Symbols	SCGB1A1 ; CC10; CC16; CCPBP; CCSP; UGB; UP-1; UP1
External IDs	OMIM: 192020 MGI: 98919 HomoloGene: 2518 GeneCards: SCGB1A1 Gene
Gene ontology Molecular function • protein binding • phospholipase A2 inhibitor activity • polychlorinated biphenyl binding Cellular component • extracellular space • nuclear envelope • rough endoplasmic reticulum • secretory granule • extracellular exosome Biological process • negative regulation of transcription from RNA polymerase II promoter • signal transduction • female pregnancy • embryo implantation • response to xenobiotic stimulus • response to ozone • response to lipopolysaccharide • negative regulation of interferon-gamma production • negative regulation of interleukin-13 production • negative regulation of interleukin-4 production • negative regulation of interleukin-5 production • response to silicon dioxide • response to cytokine • negative regulation of T cell proliferation • response to drug • negative regulation of catalytic activity • regulation of mRNA stability • regulation of inflammatory response • response to glucocorticoid • response to fibroblast growth factor Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7356	22287
Ensembl	ENSG00000149021	ENSMUSG00000024653
UniProt	P11684	Q06318
RefSeq (mRNA)	NM_003357	NM_011681
RefSeq (protein)	NP_003348	NP_035811
Location (UCSC)	Chr 11: 62.41 – 62.42 Mb	Chr 19: 9.08 – 9.09 Mb
PubMed search

Uteroglobin, also known as secretoglobin family 1A member 1 (SCGB1A1), is a protein that in humans is encoded by the SCGB1A1 gene.^[1]

SCGB1A1 is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals.^[2] This antiparallel disulfide linked homodimeric protein is multifunctional and found in various tissues in various names such as: Uteroglobin (UG, UGB), Uteroglobin-like Antigen (UGL), Blastokinin, club cell secretory protein (CCSP), Clara cell 16 kD protein (17 in rat/mice), club Cell-Specific 10 kD Protein (CC10), human protein 1, urine protein 1 (UP-1), polychlorinated biphenyl-binding protein (PCB-BP), human club Cell Phospholipid-Binding Protein (hCCPBP), Secretoglobin 1A member 1 (SCGB1A1).^[3]

This protein is specifically expressed in club cells in the lungs. (http://www.sciencedirect.com/science/article/pii/S0167478196001807)

Function

Real physiological role is not known. Putative functions are:

1. Immunomodulation:
2. Progesterone binding: weak in some animals, especially weak in humans. (Note: UGB is itself progesterone induced gene in the endometrium in Lagomorphs.)
3. Inhibits phospholipase A2 in vitro
4. binds phosphatidylcholine, phosphatidylinositol,
5. Binds to fibronectin: The uteroglobulin knockout mice on the inbred C57Bl6 strain develop Goodpasture's syndrome like glomerulopathy due to fibronectin binding of IgA which might potentially be prevented by uteroglobin replacement. However contrary to the animal model claims, human genetic data might suggest that the effect may be indirect^[4]
6. Uteroglobin knockout mice on the inbred 129 strain appear to have healthy phenotype (no glomerulopathy development), but show physiological differences in their responses to respiratory challenges. The phenotype exhibited by these mice are; decreased bioaccumulation of biphenyls, susceptibility and increased IL-13, and IL-6 following hyperoxic challenge, and changes in the club cell morphology ^[5]
7. Target of Polychlorinated biphenyl (pcb) binding

External links

• Bioinformatic_Harvester

References

1. Wolf M, Klug J, Hackenberg R, Gessler M, Grzeschik KH, Beato M, Suske G (September 1992). "Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines". Hum. Mol. Genet. 1 (6): 371–8. doi:10.1093/hmg/1.6.371. PMID 1284526.
2. Laukaitis CM, Karn RC (2005). "Evolution of the secretoglobins: a genomic and proteomic view". Biological Journal of the Linnean Society 84 (3): 493–501. doi:10.1111/j.1095-8312.2005.00450.x.
3. Klug J, Beier HM, Bernard A, Chilton BS, Fleming TP, Lehrer RI, Miele L, Pattabiraman N, Singh G (2000). "Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report". Ann. N. Y. Acad. Sci. 923: 348–54. doi:10.1111/j.1749-6632.2000.tb05549.x. PMID 11193777.
4. Vollmer M, Krapf R, Hildebrandt F (1998). "Exclusion of the uteroglobin gene as a candidate for fibronectin glomerulopathy (GFND)". Nephrol. Dial. Transplant. 13 (9): 2417–8. doi:10.1093/ndt/13.9.2417. PMID 9761542.
5. Stripp B R, Reynolds S D, Boe I, Lund J, Power J H T, Coppens, J T, Wong V, Reynolds P R, Plopper C G (2002). "Clara Cell Secretory Protein Deficiency Alters Clara Cell Secretory Apparatus and the Protein Composition of Airway Lining Fluid". Am. J. Respir. Cell Mol. Biol. 27 (2): 170–8. doi:10.1165/ajrcmb.27.2.200200270c. PMID 12151308.

Further reading

• Bernard A, Roels H, Lauwerys R, et al. (1992). "Human urinary protein 1: evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions.". Clin. Chim. Acta 207 (3): 239–49. doi:10.1016/0009-8981(92)90122-7. PMID 1395029.
• Singh G, Katyal SL, Brown WE, et al. (1988). "Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa protein.". Biochim. Biophys. Acta 950 (3): 329–37. doi:10.1016/0167-4781(88)90129-7. PMID 3167058.
• Singh G, Singh J, Katyal SL, et al. (1988). "Identification, cellular localization, isolation, and characterization of human Clara cell-specific 10 KD protein.". J. Histochem. Cytochem. 36 (1): 73–80. doi:10.1177/36.1.3275712. PMID 3275712.
• Jensen SM, Jones JE, Pass H, et al. (1994). "Clara cell 10 kDa protein mRNA in normal and atypical regions of human respiratory epithelium.". Int. J. Cancer 58 (5): 629–37. doi:10.1002/ijc.2910580503. PMID 7521325.
• Umland TC, Swaminathan S, Singh G, et al. (1995). "Structure of a human Clara cell phospholipid-binding protein-ligand complex at 1.9 A resolution.". Nat. Struct. Biol. 1 (8): 538–45. doi:10.1038/nsb0894-538. PMID 7664082.
• Hay JG, Danel C, Chu CS, Crystal RG (1995). "Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease.". Am. J. Physiol. 268 (4 Pt 1): L565–75. PMID 7733299.
• Zhang Z, Zimonjic DB, Popescu NC, et al. (1997). "Human uteroglobin gene: structure, subchromosomal localization, and polymorphism.". DNA Cell Biol. 16 (1): 73–83. doi:10.1089/dna.1997.16.73. PMID 9022046.
• Laing IA, Goldblatt J, Eber E, et al. (1998). "A polymorphism of the CC16 gene is associated with an increased risk of asthma.". J. Med. Genet. 35 (6): 463–7. doi:10.1136/jmg.35.6.463. PMC 1051339. PMID 9643286.
• Zheng F, Kundu GC, Zhang Z, et al. (1999). "Uteroglobin is essential in preventing immunoglobulin A nephropathy in mice.". Nat. Med. 5 (9): 1018–25. doi:10.1038/12458. PMID 10470078.
• Müller-Schöttle F, Classen-Linke I, Alfer J, et al. (2000). "Expression of uteroglobin in the human endometrium.". Mol. Hum. Reprod. 5 (12): 1155–61. doi:10.1093/molehr/5.12.1155. PMID 10587371.
• Kundu GC, Zhang Z, Mantile-Selvaggi G, et al. (2001). "Uteroglobin binding proteins: regulation of cellular motility and invasion in normal and cancer cells.". Ann. N. Y. Acad. Sci. 923: 234–48. doi:10.1111/j.1749-6632.2000.tb05533.x. PMID 11193760.
• Burmeister R, Boe IM, Nykjaer A, et al. (2001). "A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney.". J. Biol. Chem. 276 (16): 13295–301. doi:10.1074/jbc.M010679200. PMID 11278724.
• Matsunaga A, Numakura C, Kawakami T, et al. (2002). "Association of the uteroglobin gene polymorphism with IgA nephropathy.". Am. J. Kidney Dis. 39 (1): 36–41. doi:10.1053/ajkd.2002.29875. PMID 11774099.
• Ghafouri B, Ståhlbom B, Tagesson C, Lindahl M (2002). "Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting.". Proteomics 2 (1): 112–20. doi:10.1002/1615-9861(200201)2:1<112::AID-PROT112>3.0.CO;2-N. PMID 11788998.
• Narita I, Saito N, Goto S, et al. (2002). "Role of uteroglobin G38A polymorphism in the progression of IgA nephropathy in Japanese patients.". Kidney Int. 61 (5): 1853–8. doi:10.1046/j.1523-1755.2002.00336.x. PMID 11967037.
• Shijubo N, Itoh Y, Abe S (2002). "[Anti-inflammatory molecule, Clara cell 10 kilodalton protein and respiratory diseases]". Rinsho Byori 50 (4): 370–3. PMID 12014016.
• Chowdhury B, Mantile-Selvaggi G, Miele L, et al. (2002). "Lys 43 and Asp 46 in alpha-helix 3 of uteroglobin are essential for its phospholipase A2 inhibitory activity.". Biochem. Biophys. Res. Commun. 295 (4): 877–83. doi:10.1016/S0006-291X(02)00767-2. PMID 12127976.
• Coppo R, Chiesa M, Cirina P, et al. (2002). "In human IgA nephropathy uteroglobin does not play the role inferred from transgenic mice.". Am. J. Kidney Dis. 40 (3): 495–503. doi:10.1053/ajkd.2002.34890. PMID 12200800.
• Navab R, Wang Y, Chow YH, et al. (2002). "Regulation of human Clara cell 10 kD protein expression by chicken ovalbumin upstream promoter transcription factors (COUP-TFs).". Am. J. Respir. Cell Mol. Biol. 27 (3): 273–85. doi:10.1165/rcmb.2002-0014oc. PMID 12204889.