Strictosidine beta-glucosidase

3alpha(S)-strictosidine beta-glucosidase
Identifiers
EC number	3.2.1.105
CAS number	73379-57-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

3alpha(S)-strictosidine beta-glucosidase (EC 3.2.1.105) is an enzyme with systematic name strictosidine beta-D-glucohydrolase.^[1][2][3] This enzyme catalyses the following chemical reaction

strictosidine + H₂O $\rightleftharpoons$ D-glucose + strictosidine aglycone

Thus, the two substrates of this enzyme are strictosidine and H₂O, whereas its two products are D-glucose and strictosidine aglycone.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. This enzyme participates in indole and ipecac alkaloid biosynthesis.

Strictosidine is a precursor of indole alkaloids.

References

1. Hemscheidt, T. and Zenk, M.H. (1980). "Glucosidases involved in indole alkaloid biosynthesis of Catharanthus cell cultures". FEBS Lett. 110: 187–191. doi:10.1016/0014-5793(80)80069-X. PMID 6768587.
2. Luijendijk T.J.C., Stevens L.H., Verpoorte R. (1998). "Purification and characterisation of strictosidine beta-D-glucosidase from Catharanthus roseus cell suspension cultures". Plant Physiol. Biochem. 36: 419–425. doi:10.1016/S0981-9428(98)80205-2.
3. Barleben, L., Ma, X., Koepke, J., Peng, G., Michel, H. and Stöckigt, J. (2005). "Expression, purification, crystallization and preliminary X-ray analysis of strictosidine glucosidase, an enzyme initiating biosynthetic pathways to a unique diversity of indole alkaloid skeletons". Biochim. Biophys. Acta 1747: 89–92. doi:10.1016/j.bbapap.2004.09.026. PMID 15680242.

External links

• 3alpha(S)-strictosidine beta-glucosidase at the US National Library of Medicine Medical Subject Headings (MeSH)