UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing)

UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing) (EC 3.2.1.184, UDP-Bac2Ac4Ac 2-epimerase, NeuC) is an enzyme with systematic name UDP-N,N'-diacetylbacillosamine hydrolase (2-epimerising).^[1]^[2] This enzyme catalyses the following chemical reaction

UDP-N,N'-diacetylbacillosamine + H₂O

\rightleftharpoons

UDP + 2,4-diacetamido-2,4,6-trideoxy-D-mannopyranose

This enzyme requires Mg2+. It is involved in biosynthesis of legionaminic acid.

References

↑ Glaze, P.A., Watson, D.C., Young, N.M. and Tanner, M.E. (2008). "Biosynthesis of CMP-N,N′-diacetyllegionaminic acid from UDP-N,N′-diacetylbacillosamine in Legionella pneumophila". Biochemistry 47: 3272–3282. doi:10.1021/bi702364s. PMID 18275154.
↑ Schoenhofen, I.C., Vinogradov, E., Whitfield, D.M., Brisson, J.R. and Logan, S.M. (2009). "The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors". Glycobiology 19: 715–725. doi:10.1093/glycob/cwp039. PMID 19282391.

External links

UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing) at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: sugar hydrolases (EC 3.2)

3.2.1: Glycoside hydrolases

Disaccharidase	Sucrase/Sucrase-isomaltase/Invertase Maltase Trehalase Lactase

Glucosidases	Cellulase Alpha-glucosidase Acid Neutral AB Neutral C Beta-glucosidase cytosolic Debranching enzyme

Other	Amylase Alpha-amylase Chitinase Lysozyme Neuraminidase NEU1 NEU2 NEU3 NEU4 Bacterial neuraminidase Viral neuraminidase Galactosidases Alpha Beta alpha-Mannosidase Glucuronidase Hyaluronidase Pullulanase Glucosylceramidase lysosomal non-lysosomal Galactosylceramidase Alpha-N-acetylgalactosaminidase NAGA Alpha-N-acetylglucosaminidase Fucosidase Hexosaminidase HEXA HEXB Iduronidase Maltase-glucoamylase Heparanase HPSE2

3.2.2: Hydrolysing
N-Glycosyl compounds

DNA glycosylases: Oxoguanine glycosylase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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