Alpha-L-fucosidase

Alpha-L-fucosidase

crystal structure of thermotoga maritima alpha-fucosidase
Identifiers
Symbol Alpha_L_fucos
Pfam PF01120
Pfam clan CL0058
InterPro IPR000933
PROSITE PDOC00324
SCOP 1hl9
SUPERFAMILY 1hl9
CAZy GH29
alpha-L-fucosidase
Identifiers
EC number 3.2.1.51
CAS number 9037-65-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an alpha-L-fucosidase (EC 3.2.1.51) is an enzyme that catalyzes the chemical reaction

an alpha-L-fucoside + H2O \rightleftharpoons L-fucose + an alcohol

Thus, the two substrates of this enzyme are alpha-L-fucoside and H2O, whereas its two products are L-fucose and alcohol.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is alpha-L-fucoside fucohydrolase. This enzyme is also called alpha-fucosidase. This enzyme participates in n-glycan degradation and glycan structures - degradation.

Deficiency of this enzyme is called Fucosidosis.

In CAZy, alpha-L-fucosidases are found in glycoside hydrolase family 29 and glycoside hydrolase family 95.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1HL8, 1HL9, and 1ODU.

See also

References

    Further reading

    External links


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