Troxerutin

Troxerutin
Systematic (IUPAC) name
2-[3,4-bis(2-hydroxyethoxy)phenyl]-5-hydroxy-7-(2-hydroxyethoxy)-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-β-D-mannopyranosyl)-β-D-glucopyranoside
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
CAS Number 7085-55-4 N
ATC code C05CA04 (WHO)
PubChem CID 9896814
ChemSpider 4589027
UNII 7Y4N11PXO8 YesY
ChEMBL CHEMBL3182320 N
Synonyms Hydroxyethylrutoside (HER)
Pherarutin
Trihydroxyethylrutin
3',4',7-Tris[O-(2-hydroxyethyl)]rutin
Chemical data
Formula C33H42O19
Molar mass 742.67518 g/mol
 NYesY (what is this?)  (verify)

Troxerutin is a flavonol, a type of flavonoid. It is more accurately a hydroxyethylrutoside. It can be isolated from Sophora japonica, the Japanese pagoda tree.

It is used as a vasoprotective.[1]

Troxerutin has been shown in mice to reverse CNS insulin resistance and reduce reactive oxygen species induced by a high-cholesterol diet.[2]

References

  1. Riccioni, C.; Sarcinella, R.; Izzo, A.; Palermo, G.; Liguori, M. (2004). "Effectiveness of Troxerutin in association with Pycnogenol in the pharmacological treatment of venous insufficiency". Minerva cardioangiologica 52 (1): 43–48. PMID 14765037.
  2. Lu, J.; Wu, D. -M.; Zheng, Z. -H.; Zheng, Y. -L.; Hu, B.; Zhang, Z. -F. (2011). "Troxerutin protects against high cholesterol-induced cognitive deficits in mice". Brain 134 (3): 783–797. doi:10.1093/brain/awq376. PMID 21252113.


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