Glycoside hydrolase family 42

Beta-galactosidase
crystal structure of thermus thermophilus a4 beta-galactosidase
Identifiers
Symbol	Glyco_hydro_42
Pfam	PF02449
Pfam clan	CL0058
InterPro	IPR013529
SCOP	1kwg
SUPERFAMILY	1kwg
CAZy	GH42
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Beta-galactosidase trimerisation domain
crystal structure of thermus thermophilus a4 beta-galactosidase
Identifiers
Symbol	Glyco_hydro_42M
Pfam	PF08532
Pfam clan	CL0014
InterPro	IPR013738
SCOP	1kwg
SUPERFAMILY	1kwg
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Beta-galactosidase C-terminal domain
crystal structure of thermus thermophilus a4 beta-galactosidase
Identifiers
Symbol	Glyco_hydro_42C
Pfam	PF08533
Pfam clan	CL0369
InterPro	IPR013739
SCOP	1kwg
SUPERFAMILY	1kwg
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, glycoside hydrolase family 42 is a family of glycoside hydrolases.

Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.^[1][2][3] This classification is available on the CAZy(http://www.cazy.org/GH1.html) web site,^[4] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.^[5]

The glycosyl hydrolase 42 family CAZY GH_42 comprises beta-galactosidase enzymes (EC 3.2.1.23). These enzyme catalyse the hydrolysis of terminal, non-reducing terminal beta-D-galactoside residues. The middle domain of these three-domain enzymes is involved in trimerisation.^[6]

References

1. Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G (1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proc. Natl. Acad. Sci. U.S.A. 92 (15): 7090–7094. doi:10.1073/pnas.92.15.7090. PMC 41477. PMID 7624375.
2. Henrissat B, Davies G (1995). "Structures and mechanisms of glycosyl hydrolases". Structure 3 (9): 853–859. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
3. Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.
4. Henrissat, B. and Coutinho P.M. "Carbohydrate-Active Enzymes server". 1999.
5. CAZypedia, an online encyclopedia of carbohydrate-active enzymes.
6. Shimizu T, Kobayashi T, Ba-Thein W, Ohtani K, Hayashi H (1995). "Sequence analysis of flanking regions of the pfoA gene of Clostridium perfringens: beta-galactosidase gene (pbg) is located in the 3'-flanking region.". Microbiol Immunol 39 (9): 677–86. doi:10.1111/j.1348-0421.1995.tb03256.x. PMID 8577281.

This article incorporates text from the public domain Pfam and InterPro IPR013529

This article incorporates text from the public domain Pfam and InterPro IPR013739

This article incorporates text from the public domain Pfam and InterPro IPR013738