Glycoside hydrolase family 61

Glycosyl hydrolase family 61
Identifiers
Symbol Glyco_hydro_61
Pfam PF03443
InterPro IPR005103
CAZy GH61

In molecular biology, glycoside hydrolase family 61 is wrongly classified as a family of glycoside hydrolases. In March 2013 it was re-classified as Auxiliary Activity 9 of the CAZy system.[1]

Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[2][3][4] This classification is available on the CAZy(http://www.cazy.org/GH1.html) web site,[5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6]

AA9 is known to be a copper dependent, oxidative enzyme able to cleave crystalline cellulose.[7] Activity greatly depends on the presence of a divalent copper ion and a reductant such as gallate or ascorbate. The oxidative action of AA9 can work on either the reducing or the non-reducing end of glucose moietes.[8] Although AA9 enzymes can be found in a large spectrum of biomass degrading fungi, research into this family is relatively new.[9]

References

  1. ↑ Anthony Levasseur, Elodie Drula, Vincent Lombard, Pedro M Coutinho, and Bernard Henrissat (21 March 2013). "Expansion of the enzymatic repertoire of the CAZy database to integrate auxiliary redox enzymes". Biotechnol Biofuels 6 (41). doi:10.1186/1754-6834-6-41. PMC 3620520.
  2. ↑ Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G (1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proc. Natl. Acad. Sci. U.S.A. 92 (15): 7090–7094. doi:10.1073/pnas.92.15.7090. PMC 41477. PMID 7624375.
  3. ↑ Henrissat B, Davies G (1995). "Structures and mechanisms of glycosyl hydrolases". Structure 3 (9): 853–859. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
  4. ↑ Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.
  5. ↑ Henrissat, B. and Coutinho P.M. "Carbohydrate-Active Enzymes server". 1999.
  6. ↑ CAZypedia, an online encyclopedia of carbohydrate-active enzymes.
  7. ↑ http://www.scopus.com/record/display.url?eid=2-s2.0-81755166559&origin=resultslist&sort=plf-f&src=s&st1=Westereng&st2=B&nlo=1&nlr=20&nls=count-f&sid=D1642A3162BE5E1C47EB35DCF40BDC23.aXczxbyuHHiXgaIW6Ho7g%3a273&sot=anl&sdt=aut&sl=38&s=AU-ID%28%22Westereng%2c+Bj%c3%b8rge%22+23135999100%29&relpos=9&relpos=9&citeCnt=25&searchTerm=AU-ID%28%5C%26quot%3BWestereng%2C+Bj%C3%B8rge%5C%26quot%3B+23135999100%29
  8. ↑ http://www.scopus.com/record/display.url?eid=2-s2.0-84858287477&origin=resultslist&sort=plf-f&src=s&st1=Dimarogona&st2=M&nlo=1&nlr=20&nls=count-f&sid=D1642A3162BE5E1C47EB35DCF40BDC23.aXczxbyuHHiXgaIW6Ho7g%3a553&sot=anl&sdt=aut&sl=38&s=AU-ID%28%22Dimarogona%2c+Maria%22+36019763600%29&relpos=3&relpos=3&citeCnt=6&searchTerm=AU-ID%28%5C%26quot%3BDimarogona%2C+Maria%5C%26quot%3B+36019763600%29
  9. ↑ http://www.scopus.com/record/display.url?eid=2-s2.0-84871874790&origin=resultslist&sort=plf-f&src=s&st1=Bey&st2=M&nlo=1&nlr=20&nls=count-f&sid=D1642A3162BE5E1C47EB35DCF40BDC23.aXczxbyuHHiXgaIW6Ho7g%3a393&sot=anl&sdt=aut&sl=33&s=AU-ID%28%22Bey%2c+Mathieu%22+54792809200%29&relpos=1&relpos=1&citeCnt=5&searchTerm=AU-ID%28%5C%26quot%3BBey%2C+Mathieu%5C%26quot%3B+54792809200%29

This article incorporates text from the public domain Pfam and InterPro IPR005103

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