Glycoside hydrolase family 66

Glycosyl hydrolase family 66
Identifiers
Symbol	Glyco_hydro_66
Pfam	PF13199
Pfam clan	CL0058
CAZy	GH66
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, glycoside hydrolase family 66 is a family of glycoside hydrolases.

Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.^[1][2][3] This classification is available on the CAZy(http://www.cazy.org/GH1.html) web site,^[4] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.^[5]

Glycoside hydrolase family 66 CAZY GH_66 includes enzymes with cycloisomaltooligosaccharide glucanotransferase EC 2.4.1.248 and dextranase EC 3.2.1.11 activities.^[6][7]

References

1. Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G (1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proc. Natl. Acad. Sci. U.S.A. 92 (15): 7090–7094. doi:10.1073/pnas.92.15.7090. PMC 41477. PMID 7624375.
2. Henrissat B, Davies G (1995). "Structures and mechanisms of glycosyl hydrolases". Structure 3 (9): 853–859. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
3. Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.
4. Henrissat, B. and Coutinho P.M. "Carbohydrate-Active Enzymes server". 1999.
5. CAZypedia, an online encyclopedia of carbohydrate-active enzymes.
6. Igarashi T, Yamamoto A, Goto N (1995). "Sequence analysis of the Streptococcus mutans Ingbritt dexA gene encoding extracellular dextranase.". Microbiol Immunol 39 (11): 853–60. doi:10.1111/j.1348-0421.1995.tb03282.x. PMID 8657012.
7. Funane K, Kawabata Y, Suzuki R, Kim YM, Kang HK, Suzuki N, et al. (2011). "Deletion analysis of regions at the C-terminal part of cycloisomaltooligosaccharide glucanotransferase from Bacillus circulans T-3040.". Biochim Biophys Acta 1814 (3): 428–34. doi:10.1016/j.bbapap.2010.12.009. PMID 21193067.