Glycoside hydrolase family 98

Glycosyl hydrolase family 98
Identifiers
Symbol	Glyco_hydro_98M
Pfam	PF08306
InterPro	IPR013191
CAZy	GH98
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Glycosyl hydrolase family 98 C-terminal domain
Identifiers
Symbol	Glyco_hydro_98C
Pfam	PF08307
InterPro	IPR013190
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, glycoside hydrolase family 98 is a family of glycoside hydrolases.

Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.^[1][2][3] This classification is available on the CAZy(http://www.cazy.org/GH1.html) web site,^[4] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.^[5]

Members of glycoside hydrolase family 98 have endo-β-galactosidase activity. This family includes E-ABase from Clostridium perfringens which cleaves both blood group A and B glycotopes.^[6]

The putative catalytic domain is found to the N-terminus of a second domain, which is not expected to form part of the catalytic activity.

References

1. Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G (1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proc. Natl. Acad. Sci. U.S.A. 92 (15): 7090–7094. doi:10.1073/pnas.92.15.7090. PMC 41477. PMID 7624375.
2. Henrissat B, Davies G (1995). "Structures and mechanisms of glycosyl hydrolases". Structure 3 (9): 853–859. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
3. Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.
4. Henrissat, B. and Coutinho P.M. "Carbohydrate-Active Enzymes server". 1999.
5. CAZypedia, an online encyclopedia of carbohydrate-active enzymes.
6. Anderson KM, Ashida H, Maskos K, Dell A, Li SC, Li YT (2005). "A clostridial endo-beta-galactosidase that cleaves both blood group A and B glycotopes: the first member of a new glycoside hydrolase family, GH98.". J Biol Chem 280 (9): 7720–8. doi:10.1074/jbc.M414099200. PMID 15618227.

This article incorporates text from the public domain Pfam and InterPro IPR013190

This article incorporates text from the public domain Pfam and InterPro IPR013191