Sucrose alpha-glucosidase

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Sucrose alpha-glucosidase (EC 3.2.1.48, sucrose alpha-glucohydrolase, sucrase, sucrase-isomaltase, sucrose.alpha.-glucohydrolase, intestinal sucrase, sucrase(invertase)) is an enzyme with systematic name sucrose-alpha-D-glucohydrolase.^[1]^[2]^[3]^[4]^[5]^[6] This enzyme catalyses the following chemical reaction

Hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type action

This enzyme is isolated from intestinal mucosa as a single polypeptide chain.

References

↑ Conklin, K.A., Yamashiro, K.M. and Gray, G.M. (1975). "Human intestinal sucrase-isomaltase. Identification of free sucrase and isomaltase and cleavage of the hybrid into active distinct subunits". J. Biol. Chem. 250: 5735–5741. PMID 807575.
↑ Hauri, H.-P., Quaroni, A. and Isselbacher, K.J. (1979). "Biogenesis of intestinal plasma membrane: posttranslational route and cleavage of sucrase-isomaltase". Proc. Natl. Acad. Sci. USA 76: 5183–5186. doi:10.1073/pnas.76.10.5183. PMID 291933.
↑ Kolinska, J. and Kraml, J. (1972). "Separation and characterization of sucrose-isomaltase and of glucoamylase of rat intestine". Biochim. Biophys. Acta 284: 235–247. doi:10.1016/0005-2744(72)90062-9. PMID 5073761.
↑ Sigrist, H., Ronner, P. and Semenza, G. (1975). "A hydrophobic form of the small-intestinal sucrase-isomaltase complex". Biochim. Biophys. Acta 406: 433–446. doi:10.1016/0005-2736(75)90022-x. PMID 1182172.
↑ Sjöström, H., Norén, O., Christiansen, L., Wacker, H. and Semenza, G. (1980). "A fully active, two-active-site, single-chain sucrase-isomaltase from pig small intestine. Implications for the biosynthesis of a mammalian integral stalked membrane protein". J. Biol. Chem. 255: 11332–11338. PMID 7002920.
↑ Takesue, Y. (1969). "Purification and properties of rabbit intestinal sucrase". J. Biochem. (Tokyo) 65: 545–552. PMID 5804876.

External links

Sucrose alpha-glucosidase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: sugar hydrolases (EC 3.2)

3.2.1: Glycoside hydrolases

Disaccharidase	Sucrase/Sucrase-isomaltase/Invertase Maltase Trehalase Lactase

Glucosidases	Cellulase Alpha-glucosidase Acid Neutral AB Neutral C Beta-glucosidase cytosolic Debranching enzyme

Other	Amylase Alpha-amylase Chitinase Lysozyme Neuraminidase NEU1 NEU2 NEU3 NEU4 Bacterial neuraminidase Viral neuraminidase Galactosidases Alpha Beta alpha-Mannosidase Glucuronidase Hyaluronidase Pullulanase Glucosylceramidase lysosomal non-lysosomal Galactosylceramidase Alpha-N-acetylgalactosaminidase NAGA Alpha-N-acetylglucosaminidase Fucosidase Hexosaminidase HEXA HEXB Iduronidase Maltase-glucoamylase Heparanase HPSE2

3.2.2: Hydrolysing
N-Glycosyl compounds

DNA glycosylases: Oxoguanine glycosylase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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