ADCY1

Adenylate cyclase 1 (brain)
Identifiers
Symbols	ADCY1 ; AC1; DFNB44
External IDs	OMIM: 103072 MGI: 99677 HomoloGene: 41419 IUPHAR: 1278 ChEMBL: 2899 GeneCards: ADCY1 Gene
EC number	4.6.1.1
Gene ontology Molecular function • calmodulin binding • ATP binding • calcium- and calmodulin-responsive adenylate cyclase activity • metal ion binding Cellular component • nucleus • cytoplasm • plasma membrane • integral component of membrane • extracellular exosome Biological process • renal water homeostasis • energy reserve metabolic process • cAMP biosynthetic process • water transport • signal transduction • epidermal growth factor receptor signaling pathway • adenylate cyclase-activating G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • activation of phospholipase C activity • synaptic transmission • axonogenesis • long-term memory • circadian rhythm • fibroblast growth factor receptor signaling pathway • response to lithium ion • activation of protein kinase A activity • intracellular signal transduction • response to drug • regulation of circadian rhythm • small molecule metabolic process • innate immune response • neurotrophin TRK receptor signaling pathway • transmembrane transport • cellular response to glucagon stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	107	432530
Ensembl	ENSG00000164742	ENSMUSG00000020431
UniProt	Q08828	O88444
RefSeq (mRNA)	NM_001281768	NM_009622
RefSeq (protein)	NP_001268697	NP_033752
Location (UCSC)	Chr 7: 45.57 – 45.72 Mb	Chr 11: 7.06 – 7.18 Mb
PubMed search

Adenylyl cyclase type 1 is an enzyme that in humans is encoded by the ADCY1 gene.^[1][2]

This gene encodes a form of adenylyl cyclase expressed in brain. A similar protein in mice is involved in pattern formation of the brain.^[2]

Function

ADCY1 is a calmodulin-sensitive adenylyl cyclase. In terms of function, It may be involved in regulatory processes in the central nervous system; specifically, it may play a role in memory acquisition and learning. It is inhibited by the G protein beta and gamma subunit complex.^[3]

References

1. Villacres EC, Xia Z, Bookbinder LH, Edelhoff S, Disteche CM, Storm DR (May 1993). "Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase". Genomics 16 (2): 473–8. doi:10.1006/geno.1993.1213. PMID 8314585.
2. "Entrez Gene: ADCY1 adenylyl cyclase 1 (brain)".
3. "Gene Cards: ADCY1 Gene". Retrieved 2012-12-30.

Further reading

• Osawa S, Dhanasekaran N, Woon CW, Johnson GL (Nov 1990). "G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex interactions". Cell 63 (4): 697–706. doi:10.1016/0092-8674(90)90136-3. PMID 2121366.
• Gaudin C, Homcy CJ, Ishikawa Y (Nov 1994). "Mammalian adenylyl cyclase family members are randomly located on different chromosomes". Human Genetics 94 (5): 527–9. doi:10.1007/BF00211020. PMID 7959689.
• Whisnant RE, Gilman AG, Dessauer CW (Jun 1996). "Interaction of the two cytosolic domains of mammalian adenylyl cyclase". Proceedings of the National Academy of Sciences of the United States of America 93 (13): 6621–5. doi:10.1073/pnas.93.13.6621. PMC 39075. PMID 8692867.
• Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (Mar 1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Archiv 437 (4): 538–46. doi:10.1007/s004240050815. PMID 10089566.
• Speth C, Joebstl B, Barcova M, Dierich MP (Apr 2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS 14 (6): 629–36. doi:10.1097/00002030-200004140-00001. PMID 10807185.
• Patke CL, Shearer WT (May 2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". The Journal of Allergy and Clinical Immunology 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179.
• Patrizio M, Colucci M, Levi G (Apr 2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". Journal of Neurochemistry 77 (2): 399–407. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302.
• Côté M, Guillon G, Payet MD, Gallo-Payet N (Sep 2001). "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland". The Journal of Clinical Endocrinology and Metabolism 86 (9): 4495–503. doi:10.1210/jc.86.9.4495. PMID 11549699.
• Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP (Apr 2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons". Journal of Virology 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMC 136041. PMID 11884542.
• Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". Journal of Receptor and Signal Transduction Research 22 (1-4): 79–110. doi:10.1081/RRS-120014589. PMID 12503609.
• Tucholski J, Johnson GV (Jul 2003). "Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation". The Journal of Biological Chemistry 278 (29): 26838–43. doi:10.1074/jbc.M303683200. PMID 12743114.
• Wang H, Ferguson GD, Pineda VV, Cundiff PE, Storm DR (Jun 2004). "Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP". Nature Neuroscience 7 (6): 635–42. doi:10.1038/nn1248. PMID 15133516.
• Vortherms TA, Nguyen CH, Berlot CH, Watts VJ (Dec 2004). "Using molecular tools to dissect the role of Galphas in sensitization of AC1". Molecular Pharmacology 66 (6): 1617–24. doi:10.1124/mol.104.000166. PMID 15361543.
• Weber B, Schaper C, Scholz J, Bein B, Rodde C, H Tonner P (Oct 2006). "Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase". Cellular Signalling 18 (10): 1748–57. doi:10.1016/j.cellsig.2006.01.017. PMID 16531006.
• Nlend MC, Schmid A, Sutto Z, Ransford GA, Conner GE, Fregien N, Salathe M (Jul 2007). "Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia". FEBS Letters 581 (17): 3241–6. doi:10.1016/j.febslet.2007.06.015. PMC 1986749. PMID 17586501.