GUCY1A3

Guanylate cyclase 1, soluble, alpha 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3UVJ​, 4NI2​
Identifiers
Symbols	GUCY1A3 ; GC-SA3; GUC1A3; GUCA3; GUCSA3; GUCY1A1; MYMY6
External IDs	OMIM: 139396 MGI: 1926562 HomoloGene: 37360 IUPHAR: 1288 ChEMBL: 3796 GeneCards: GUCY1A3 Gene
EC number	4.6.1.2
Gene ontology Molecular function • guanylate cyclase activity • receptor activity • GTP binding • heme binding • protein heterodimerization activity Cellular component • guanylate cyclase complex, soluble Biological process • cGMP biosynthetic process • nitric oxide mediated signal transduction • blood coagulation • blood circulation • regulation of blood pressure • response to herbicide • response to organic cyclic compound • positive regulation of cGMP biosynthetic process • response to defense-related host nitric oxide production • relaxation of vascular smooth muscle Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2982	60596
Ensembl	ENSG00000164116	ENSMUSG00000033910
UniProt	Q02108	Q9ERL9
RefSeq (mRNA)	NM_000856	NM_021896
RefSeq (protein)	NP_000847	NP_068696
Location (UCSC)	Chr 4: 155.67 – 155.73 Mb	Chr 3: 82.09 – 82.15 Mb
PubMed search

Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene.^[1][2]

Function

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.^[2] Mutations in this gene have been associated to cases of myocardial infarction (10.1038/nature12722).

References

1. Giuili G, Scholl U, Bulle F, Guellaen G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257.
2. "Entrez Gene: GUCY1A3 guanylate cyclase 1, soluble, alpha 3".

Further reading

• Giuili G, Roechel N, Scholl U, et al. (1993). "Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33.". Hum. Genet. 91 (3): 257–60. doi:10.1007/BF00218267. PMID 8097486.
• Papapetropoulos A, Cziraki A, Rubin JW, et al. (1996). "cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue.". J. Cell. Physiol. 167 (2): 213–21. doi:10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S. PMID 8613461.
• Zabel U, Weeger M, La M, Schmidt HH (1998). "Human soluble guanylate cyclase: functional expression and revised isoenzyme family.". Biochem. J. 335 (1): 51–7. PMC 1219751. PMID 9742212.
• Zhou Y, Zheng JB, Gu X, et al. (2000). "A novel Pax-6 binding site in rodent B1 repetitive elements: coevolution between developmental regulation and repeated elements?". Gene 245 (2): 319–28. doi:10.1016/S0378-1119(00)00019-6. PMID 10717483.
• Behrends S, Vehse K, Scholz H, et al. (2000). "Assignment of GUCY1A3, a candidate gene for hypertension, to human chromosome bands 4q31.1→q31.2 by in situ hybridization.". Cytogenet. Cell Genet. 88 (3–4): 204–5. doi:10.1159/000015548. PMID 10828587.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Saino M, Maruyama T, Sekiya T, et al. (2005). "Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3". Oncol. Rep. 12 (1): 47–52. doi:10.3892/or.12.1.47. PMID 15201957.
• Meurer S, Pioch S, Wagner K, et al. (2005). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–54. doi:10.1074/jbc.M410565200. PMID 15381706.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.