FAD-AMP lyase (cyclizing)

FAD-AMP lyase (cyclizing)
Identifiers
EC number	4.6.1.15
CAS number	208349-48-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, a FAD-AMP lyase (cyclizing) (EC 4.6.1.15) is an enzyme that catalyzes the chemical reaction

FAD $\rightleftharpoons$ AMP + riboflavin cyclic-4',5'-phosphate

Hence, this enzyme has one substrate, FAD, and two products, AMP and riboflavin cyclic-4',5'-phosphate.

This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming). Other names in common use include FMN cyclase, and FAD AMP-lyase (cyclic-FMN-forming).

References

• Cameselle JC; Pinto, RM; Costas, MJ; Aavalos, M; Canales, J; Cabezas, A; Cameselle, JC (1998). "Enzymic formation of riboflavin 4',5'-cyclic phosphate from FAD: evidence for a specific low-Km FMN cyclase in rat liver1". Biochem. J. 330 (Pt 2): 881–8. PMC 1219220. PMID 9480905.
• Cameselle JC; Pinto, RM; Fraiz, F; Canales, J; González-Santiago, S; Cameselle, JC (2001). "Purification, characterization, and substrate and inhibitor structure-activity studies of rat liver FAD-AMP lyase (cyclizing): preference for FAD and specificity for splitting ribonucleoside diphosphate-X into ribonucleotide and a five-atom cyclic phosphodiester of X, either a monocyclic compound or a cis-bicyclic phosphodiester-pyranose fusion". Biochemistry. 40 (45): 13710–22. doi:10.1021/bi0157159. PMID 11695920.