ADCY7

Adenylate cyclase 7
Identifiers
Symbols	ADCY7 ; AC7
External IDs	OMIM: 600385 MGI: 102891 HomoloGene: 866 ChEMBL: 4922 GeneCards: ADCY7 Gene
EC number	4.6.1.1
Gene ontology Molecular function • adenylate cyclase activity • ATP binding • metal ion binding Cellular component • intracellular • plasma membrane • integral component of membrane Biological process • renal water homeostasis • energy reserve metabolic process • cAMP biosynthetic process • water transport • signal transduction • epidermal growth factor receptor signaling pathway • adenylate cyclase-activating G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • activation of phospholipase C activity • synaptic transmission • fibroblast growth factor receptor signaling pathway • positive regulation of cAMP biosynthetic process • activation of protein kinase A activity • intracellular signal transduction • small molecule metabolic process • innate immune response • neurotrophin TRK receptor signaling pathway • transmembrane transport • maternal process involved in female pregnancy • cellular response to ethanol • cellular response to glucagon stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	113	11513
Ensembl	ENSG00000121281	ENSMUSG00000031659
UniProt	P51828	P51829
RefSeq (mRNA)	NM_001114	NM_001037723
RefSeq (protein)	NP_001105	NP_001032812
Location (UCSC)	Chr 16: 50.25 – 50.32 Mb	Chr 8: 88.27 – 88.33 Mb
PubMed search

Adenylyl cyclase type 7 is an enzyme that in humans is encoded by the ADCY7 gene.^[1][2]

Function

This gene encodes a membrane-bound adenylyl cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences.^[2]

References

1. Hellevuo K, Berry R, Sikela JM, Tabakoff B (Mar 1995). "Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16". Hum Genet 95 (2): 197–200. doi:10.1007/bf00209401. PMID 7860067.
2. "Entrez Gene: ADCY7 adenylate cyclase 7".

Further reading

• Nomura N, Miyajima N, Sazuka T; et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
• Nomura N, Miyajima N, Sazuka T; et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
• Hellevuo K, Welborn R, Menninger JA, Tabakoff B (1997). "Human adenylyl cyclase type 7 contains polymorphic repeats in the 3' untranslated region: investigations of association with alcoholism". Am. J. Med. Genet. 74 (1): 95–8. doi:10.1002/(SICI)1096-8628(19970221)74:1<95::AID-AJMG19>3.0.CO;2-M. PMID 9034014.
• Barcova M, Speth C, Kacani L; et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflugers Arch. 437 (4): 538–46. doi:10.1007/s004240050815. PMID 10089566.
• Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS 14 (6): 629–36. doi:10.1097/00002030-200004140-00001. PMID 10807185.
• Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". J. Allergy Clin. Immunol. 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179.
• Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302.
• Yan SZ, Tang WJ (2002). "Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase". Meth. Enzymol. Methods in Enzymology 345: 231–41. doi:10.1016/S0076-6879(02)45019-7. ISBN 978-0-12-182246-0. PMID 11665607.
• Speth C, Schabetsberger T, Mohsenipour I; et al. (2002). "Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons". J. Virol. 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMC 136041. PMID 11884542.
• Nelson EJ, Hellevuo K, Yoshimura M, Tabakoff B (2003). "Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta". J. Biol. Chem. 278 (7): 4552–60. doi:10.1074/jbc.M210386200. PMID 12454008.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". J. Recept. Signal Transduct. Res. 22 (1–4): 79–110. doi:10.1081/RRS-120014589. PMID 12503609.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beeler JA, Yan SZ, Bykov S; et al. (2005). "A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase". Biochemistry 43 (49): 15463–71. doi:10.1021/bi049088. PMID 15581358.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Hines LM, Hoffman PL, Bhave S; et al. (2006). "A sex-specific role of type VII adenylyl cyclase in depression". J. Neurosci. 26 (48): 12609–19. doi:10.1523/JNEUROSCI.1040-06.2006. PMID 17135423.