ADCY9

Adenylate cyclase 9
Identifiers
Symbols	ADCY9 ; AC9
External IDs	OMIM: 603302 MGI: 108450 HomoloGene: 868 ChEMBL: 2655 GeneCards: ADCY9 Gene
EC number	4.6.1.1
Gene ontology Molecular function • adenylate cyclase activity • ATP binding • metal ion binding Cellular component • intracellular • plasma membrane • integral component of plasma membrane Biological process • renal water homeostasis • energy reserve metabolic process • cAMP biosynthetic process • water transport • signal transduction • epidermal growth factor receptor signaling pathway • adenylate cyclase-activating G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • activation of phospholipase C activity • synaptic transmission • fibroblast growth factor receptor signaling pathway • activation of protein kinase A activity • intracellular signal transduction • small molecule metabolic process • innate immune response • neurotrophin TRK receptor signaling pathway • transmembrane transport • cellular response to glucagon stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	115	11515
Ensembl	ENSG00000162104	ENSMUSG00000005580
UniProt	O60503	P51830
RefSeq (mRNA)	NM_001116	NM_001291910
RefSeq (protein)	NP_001107	NP_001278839
Location (UCSC)	Chr 16: 3.95 – 4.12 Mb	Chr 16: 4.29 – 4.42 Mb
PubMed search

Adenylyl cyclase type 9 is an enzyme that in humans is encoded by the ADCY9 gene.^[1][2]

Function

Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin.^[2]

References

1. Hacker BM, Tomlinson JE, Wayman GA, Sultana R, Chan G, Villacres E, Disteche C, Storm DR (Apr 1999). "Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9)". Genomics 50 (1): 97–104. doi:10.1006/geno.1998.5293. PMID 9628827.
2. "Entrez Gene: ADCY9 adenylate cyclase 9".

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Paterson JM, Smith SM, Harmar AJ, Antoni FA (1995). "Control of a novel adenylyl cyclase by calcineurin.". Biochem. Biophys. Res. Commun. 214 (3): 1000–8. doi:10.1006/bbrc.1995.2385. PMID 7575502.
• Premont RT, Matsuoka I, Mattei MG; et al. (1996). "Identification and characterization of a widely expressed form of adenylyl cyclase.". J. Biol. Chem. 271 (23): 13900–7. doi:10.1074/jbc.271.23.13900. PMID 8662814.
• Nagase T, Ishikawa K, Miyajima N; et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
• Barcova M, Speth C, Kacani L; et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.". Pflugers Arch. 437 (4): 538–46. doi:10.1007/s004240050815. PMID 10089566.
• Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.". AIDS 14 (6): 629–36. doi:10.1097/00002030-200004140-00001. PMID 10807185.
• Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.". J. Allergy Clin. Immunol. 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179.
• Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.". J. Neurochem. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302.
• Toyota T, Hattori E, Meerabux J; et al. (2002). "Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders.". Am. J. Med. Genet. 114 (1): 84–92. doi:10.1002/ajmg.10117. PMID 11840511.
• Speth C, Schabetsberger T, Mohsenipour I; et al. (2002). "Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons". J. Virol. 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMC 136041. PMID 11884542.
• Toyota T, Yamada K, Saito K; et al. (2002). "Association analysis of adenylate cyclase type 9 gene using pedigree disequilibrium test in bipolar disorder". Mol. Psychiatry 7 (5): 450–2. doi:10.1038/sj.mp.4000992. PMID 12082561.
• Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". J. Recept. Signal Transduct. Res. 22 (1–4): 79–110. doi:10.1081/RRS-120014589. PMID 12503609.
• Small KM, Brown KM, Theiss CT; et al. (2004). "An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation". Pharmacogenetics 13 (9): 535–41. doi:10.1097/00008571-200309000-00002. PMID 12972952.
• Cumbay MG, Watts VJ (2004). "Novel regulatory properties of human type 9 adenylate cyclase". J. Pharmacol. Exp. Ther. 310 (1): 108–15. doi:10.1124/jpet.104.065748. PMID 14996950.
• Tantisira KG, Small KM, Litonjua AA; et al. (2005). "Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways". Hum. Mol. Genet. 14 (12): 1671–7. doi:10.1093/hmg/ddi175. PMID 15879435.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.