GUCY1B3

Guanylate cyclase 1, soluble, beta 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2WZ1​, 3UVJ​, 4NI2​
Identifiers
Symbols	GUCY1B3 ; GC-S-beta-1; GC-SB3; GUC1B3; GUCB3; GUCSB3; GUCY1B1
External IDs	OMIM: 139397 MGI: 1860604 HomoloGene: 664 ChEMBL: 2046 GeneCards: GUCY1B3 Gene
EC number	4.6.1.2
Gene ontology Molecular function • guanylate cyclase activity • receptor activity • GTP binding • heme binding • metal ion binding • protein heterodimerization activity • Hsp90 protein binding Cellular component • cytoplasm • guanylate cyclase complex, soluble • intracellular membrane-bounded organelle Biological process • cGMP biosynthetic process • nitric oxide mediated signal transduction • blood coagulation • blood circulation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2983	54195
Ensembl	ENSG00000061918	ENSMUSG00000028005
UniProt	Q02153	O54865
RefSeq (mRNA)	NM_000857	NM_001161796
RefSeq (protein)	NP_000848	NP_001155268
Location (UCSC)	Chr 4: 155.76 – 155.81 Mb	Chr 3: 82.03 – 82.07 Mb
PubMed search

Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.^[1][2]

Function

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.^[2]

Interactions

GUCY1B3 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1^[3] and Endothelial NOS.^[3]

References

1. Giuili G, Scholl U, Bulle F, Guellaën G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257.
2. "Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3".
3. Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD (Aug 2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. 285 (2): H669–78. doi:10.1152/ajpheart.01025.2002. PMID 12676772.

Further reading

• Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA (2000). "Guanylyl cyclases and signaling by cyclic GMP". Pharmacol. Rev. 52 (3): 375–414. PMID 10977868.
• Chhajlani V, Frändberg PA, Ahlner J, Axelsson KL, Wikberg JE (1991). "Heterogeneity in human soluble guanylate cyclase due to alternative splicing". FEBS Lett. 290 (1–2): 157–8. doi:10.1016/0014-5793(91)81248-7. PMID 1680753.
• Giuili G, Roechel N, Scholl U, Mattei MG, Guellaen G (1993). "Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33". Hum. Genet. 91 (3): 257–60. doi:10.1007/BF00218267. PMID 8097486.
• Papapetropoulos A, Cziraki A, Rubin JW, Stone CD, Catravas JD (1996). "cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue". J. Cell. Physiol. 167 (2): 213–21. doi:10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S. PMID 8613461.
• Zabel U, Weeger M, La M, Schmidt HH (1998). "Human soluble guanylate cyclase: functional expression and revised isoenzyme family". Biochem. J. 335 (1): 51–7. PMC 1219751. PMID 9742212.
• Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes". J. Biol. Chem. 276 (48): 44647–52. doi:10.1074/jbc.M105587200. PMID 11572861.
• Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD (2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. 285 (2): H669–78. doi:10.1152/ajpheart.01025.2002. PMID 12676772.
• Meurer S, Pioch S, Wagner K, Müller-Esterl W, Gross S (2005). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–54. doi:10.1074/jbc.M410565200. PMID 15381706.
• Mateos-Cáceres PJ, Garcia-Cardoso J, Lapuente L, Zamorano-León JJ, Sacristán D, de Prada TP, Calahorra J, Macaya C, Vela-Navarrete R, López-Farré AJ (2006). "Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction". Int. J. Impot. Res. 18 (5): 432–7. doi:10.1038/sj.ijir.3901461. PMID 16528291.