NPR2

Natriuretic peptide receptor 2
Identifiers
Symbols	NPR2 ; AMDM; ANPRB; ANPb; ECDM; GUC2B; GUCY2B; NPRB; NPRBi
External IDs	OMIM: 108961 MGI: 97372 HomoloGene: 2970 IUPHAR: 1748 ChEMBL: 1795 GeneCards: NPR2 Gene
EC number	4.6.1.2
Gene ontology Molecular function • guanylate cyclase activity • protein kinase activity • receptor activity • transmembrane signaling receptor activity • ATP binding • GTP binding • natriuretic peptide receptor activity • peptide hormone binding • hormone binding • identical protein binding Cellular component • intracellular • plasma membrane • integral component of membrane Biological process • ossification • cGMP biosynthetic process • protein phosphorylation • signal transduction • cell surface receptor signaling pathway • receptor guanylyl cyclase signaling pathway • regulation of blood pressure • intracellular signal transduction • single organism reproductive process • negative regulation of meiotic cell cycle • bone development • cellular response to granulocyte macrophage colony-stimulating factor stimulus • negative regulation of oocyte maturation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4882	230103
Ensembl	ENSG00000159899	ENSMUSG00000028469
UniProt	P20594	Q6VVW5
RefSeq (mRNA)	NM_000907	NM_173788
RefSeq (protein)	NP_003986	NP_776149
Location (UCSC)	Chr 9: 35.79 – 35.81 Mb	Chr 4: 43.63 – 43.65 Mb
PubMed search

Natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B), also known as NPR2, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR2 gene.^[1]

See also

• Atrial natriuretic peptide receptor

References

1. "Entrez Gene: NPR2 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)".

Further reading

• Fox AA, Collard CD, Shernan SK, et al. (2009). "Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.". Anesthesiology 110 (4): 738–47. doi:10.1097/ALN.0b013e31819c7496. PMC 2735337. PMID 19326473.
• Potthast R, Abbey-Hosch SE, Antos LK, et al. (2004). "Calcium-dependent dephosphorylation mediates the hyperosmotic and lysophosphatidic acid-dependent inhibition of natriuretic peptide receptor-B/guanylyl cyclase-B.". J. Biol. Chem. 279 (47): 48513–9. doi:10.1074/jbc.M408247200. PMID 15371450.
• Liew D, Schneider H, D'Agostino J, et al. (2004). "Utility of B-type natriuretic peptide as a screen for left ventricular dysfunction in patients with diabetes: response to Epshteyn et al.". Diabetes Care 27 (3): 848; author reply 848–9. doi:10.2337/diacare.27.3.848. PMID 14988324.
• Antos LK, Abbey-Hosch SE, Flora DR, Potter LR (2005). "ATP-independent activation of natriuretic peptide receptors.". J. Biol. Chem. 280 (29): 26928–32. doi:10.1074/jbc.M505648200. PMID 15911610.
• Poreba R, Poczatek K, Gać P; et al. (2009). "SNP rs198389 (T-381 C) polymorphism in the B-type natriuretic peptide gene promoter in patients with atherosclerotic renovascular hypertension.". Pol. Arch. Med. Wewn. 119 (4): 219–24. PMID 19413180.
• Koller KJ, Goeddel DV (1992). "Molecular biology of the natriuretic peptides and their receptors.". Circulation 86 (4): 1081–8. doi:10.1161/01.cir.86.4.1081. PMID 1327579.
• Fan D, Bryan PM, Antos LK, et al. (2005). "Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize.". Mol. Pharmacol. 67 (1): 174–83. doi:10.1124/mol.104.002436. PMID 15459247.
• Pagel-Langenickel I, Buttgereit J, Bader M, Langenickel TH (2007). "Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy.". J. Mol. Med. 85 (8): 797–810. doi:10.1007/s00109-007-0183-4. PMID 17429599.
• Rahmutula D, Cui J, Chen S, Gardner DG (2004). "Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1.". Hypertension 44 (3): 283–8. doi:10.1161/01.HYP.0000136908.60317.92. PMID 15262909.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Hume AN, Buttgereit J, Al-Awadhi AM, et al. (2009). "Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux.". Hum. Mol. Genet. 18 (2): 267–77. doi:10.1093/hmg/ddn354. PMC 2638773. PMID 18945719.
• Schulz S (2005). "C-type natriuretic peptide and guanylyl cyclase B receptor.". Peptides 26 (6): 1024–34. doi:10.1016/j.peptides.2004.08.027. PMID 15911070.
• Tsuji T, Kunieda T (2005). "A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse.". J. Biol. Chem. 280 (14): 14288–92. doi:10.1074/jbc.C500024200. PMID 15722353.
• Dickey DM, Yoder AR, Potter LR (2009). "A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation.". J. Biol. Chem. 284 (29): 19196–202. doi:10.1074/jbc.M109.010777. PMC 2740543. PMID 19458086.
• Nozohoor S, Nilsson J, Lührs C, et al. (2009). "B-type natriuretic peptide as a predictor of postoperative heart failure after aortic valve replacement.". J. Cardiothorac. Vasc. Anesth. 23 (2): 161–5. doi:10.1053/j.jvca.2008.11.006. PMID 19167912.
• Hachiya R, Ohashi Y, Kamei Y, et al. (2007). "Intact kinase homology domain of natriuretic peptide receptor-B is essential for skeletal development.". J. Clin. Endocrinol. Metab. 92 (10): 4009–14. doi:10.1210/jc.2007-1101. PMID 17652215.
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bartels CF, Bükülmez H, Padayatti P, et al. (2004). "Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux.". Am. J. Hum. Genet. 75 (1): 27–34. doi:10.1086/422013. PMC 1182004. PMID 15146390.
• van den Akker F (2001). "Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors.". J. Mol. Biol. 311 (5): 923–37. doi:10.1006/jmbi.2001.4922. PMID 11556325.

External links

• NPR2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.