PTPRH

Protein tyrosine phosphatase, receptor type, H
Identifiers
Symbols	PTPRH ; R-PTP-H; SAP1
External IDs	OMIM: 602510 HomoloGene: 37693 GeneCards: PTPRH Gene
EC number	3.1.3.48
Gene ontology Molecular function • transmembrane receptor protein tyrosine phosphatase activity • protein binding Cellular component • cytoplasm • integral component of plasma membrane Biological process • protein dephosphorylation • apoptotic process • peptidyl-tyrosine dephosphorylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5794	545902
Ensembl	ENSG00000080031	ENSMUSG00000035429
UniProt	Q9HD43	E9Q0N2
RefSeq (mRNA)	NM_001161440	NM_207270
RefSeq (protein)	NP_001154912	NP_997153
Location (UCSC)	Chr 19: 55.18 – 55.21 Mb	Chr 7: 4.55 – 4.6 Mb
PubMed search

Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH gene.^[1][2]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues.^[2]

References

1. Matozaki T, Suzuki T, Uchida T, Inazawa J, Ariyama T, Matsuda K, Horita K, Noguchi H, Mizuno H, Sakamoto C; et al. (Feb 1994). "Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers". J Biol Chem 269 (3): 2075–81. PMID 8294459.
2. "Entrez Gene: PTPRH protein tyrosine phosphatase, receptor type, H".

Further reading

• Noguchi T, Tsuda M, Takeda H, et al. (2001). "Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas". J. Biol. Chem. 276 (18): 15216–24. doi:10.1074/jbc.M007208200. PMID 11278335.
• Marneros AG, Mehenni H, Reichenberger E, et al. (2001). "Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome". Cytogenet. Cell Genet. 92 (3–4): 213–6. doi:10.1159/000056905. PMID 11435690.
• Takada T, Noguchi T, Inagaki K, et al. (2002). "Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1". J. Biol. Chem. 277 (37): 34359–66. doi:10.1074/jbc.M206541200. PMID 12101188.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagano H, Noguchi T, Inagaki K, et al. (2003). "Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma". Oncogene 22 (30): 4656–63. doi:10.1038/sj.onc.1206588. PMID 12879010.
• Pasquali C, Curchod ML, Wälchli S, et al. (2004). "Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor". Mol. Endocrinol. 17 (11): 2228–39. doi:10.1210/me.2003-0011. PMID 12907755.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.