RNGTT

RNA guanylyltransferase and 5'-phosphatase
PDB rendering based on 1i9s.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2C46​, 3S24​
Identifiers
Symbols	RNGTT ; CAP1A; HCE; HCE1; hCAP
External IDs	OMIM: 603512 MGI: 1329041 HomoloGene: 37851 GeneCards: RNGTT Gene
EC number	2.7.7.50, 3.1.3.33
Gene ontology Molecular function • mRNA guanylyltransferase activity • polynucleotide 5'-phosphatase activity • protein tyrosine phosphatase activity • GTP binding • protein tyrosine/serine/threonine phosphatase activity • RNA guanylyltransferase activity • triphosphatase activity Cellular component • nucleus • nucleoplasm Biological process • transcription from RNA polymerase II promoter • 7-methylguanosine mRNA capping • RNA processing • gene expression • viral process • peptidyl-tyrosine dephosphorylation • polynucleotide 5' dephosphorylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8732	24018
Ensembl	ENSG00000111880	ENSMUSG00000028274
UniProt	O60942	O55236
RefSeq (mRNA)	NM_001286426	NM_001305273
RefSeq (protein)	NP_001273355	NP_001292202
Location (UCSC)	Chr 6: 88.61 – 88.96 Mb	Chr 4: 33.31 – 33.5 Mb
PubMed search

mRNA-capping enzyme is a protein that in humans is encoded by the RNGTT gene.^[1][2][3]

References

1. Pillutla RC, Shimamoto A, Furuichi Y, Shatkin AJ (Jan 1999). "Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively". Genomics 54 (2): 351–3. doi:10.1006/geno.1998.5604. PMID 9828141.
2. Yamada-Okabe T, Doi R, Shimmi O, Arisawa M, Yamada-Okabe H (May 1998). "Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme". Nucleic Acids Res 26 (7): 1700–6. doi:10.1093/nar/26.7.1700. PMC 147440. PMID 9512541.
3. "Entrez Gene: RNGTT RNA guanylyltransferase and 5'-phosphatase".

Further reading

• Yue Z, Maldonado E, Pillutla R, et al. (1998). "Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12898–903. doi:10.1073/pnas.94.24.12898. PMC 24235. PMID 9371772.
• Tsukamoto T, Shibagaki Y, Murakoshi T, et al. (1998). "Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme". Biochem. Biophys. Res. Commun. 243 (1): 101–8. doi:10.1006/bbrc.1997.8038. PMID 9473487.
• Pillutla RC, Yue Z, Maldonado E, Shatkin AJ (1998). "Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes". J. Biol. Chem. 273 (34): 21443–6. doi:10.1074/jbc.273.34.21443. PMID 9705270.
• Wen Y, Shatkin AJ (1999). "Transcription elongation factor hSPT5 stimulates mRNA capping". Genes Dev. 13 (14): 1774–9. doi:10.1101/gad.13.14.1774. PMC 316881. PMID 10421630.
• Chiu YL, Coronel E, Ho CK, et al. (2001). "HIV-1 Tat protein interacts with mammalian capping enzyme and stimulates capping of TAR RNA". J. Biol. Chem. 276 (16): 12959–66. doi:10.1074/jbc.M007901200. PMID 11278368.
• Chiu YL, Ho CK, Saha N, et al. (2002). "Tat stimulates cotranscriptional capping of HIV mRNA". Mol. Cell 10 (3): 585–97. doi:10.1016/S1097-2765(02)00630-5. PMID 12408826.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhou M, Deng L, Kashanchi F, et al. (2004). "The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA". Proc. Natl. Acad. Sci. U.S.A. 100 (22): 12666–71. doi:10.1073/pnas.1835726100. PMC 240675. PMID 14569024.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.