TPTE
| Transmembrane phosphatase with tensin homology | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TPTE ; CT44; PTEN2 | ||||||||||||
| External IDs | OMIM: 604336 MGI: 2446460 HomoloGene: 50411 GeneCards: TPTE Gene | ||||||||||||
| EC number | 3.1.3.48 | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 7179 | 234129 | |||||||||||
| Ensembl | ENSG00000274391 | ENSMUSG00000031481 | |||||||||||
| UniProt | P56180 | E9Q3G1 | |||||||||||
| RefSeq (mRNA) | NM_001290224 | NM_181851.3 | |||||||||||
| RefSeq (protein) | NP_001277153 | NP_954866.2 | |||||||||||
| Location (UCSC) |
Chr 21: 10.52 – 10.61 Mb |
Chr 8: 23.39 – 23.48 Mb | |||||||||||
| PubMed search | |||||||||||||
Putative tyrosine-protein phosphatase TPTE is an enzyme that in humans is encoded by the TPTE gene.[1][2]
Function
TPTE is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[2] TPTE is believed to lack phosphatase activity; however, the closely related protein TPIP, also called TPTE2 is an active phosphatase with activity against inositol phospholipid substrates.[3] TPTE and TPIP are the mammalian homologues to the family of voltage sensitive phosphatases.
References
- ↑ Tapparel C, Reymond A, Girardet C, Guillou L, Lyle R, Lamon C, Hutter P, Antonarakis SE (Dec 2003). "The TPTE gene family: cellular expression, subcellular localization and alternative splicing". Gene 323: 189–99. doi:10.1016/j.gene.2003.09.038. PMID 14659893.
- 1 2 "Entrez Gene: TPTE transmembrane phosphatase with tensin homology".
- ↑ Leslie NR, Yang X, Downes CP, Weijer CJ (January 2007). "PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration". Curr. Biol. 17 (2): 115–25. doi:10.1016/j.cub.2006.12.026. PMC 1885949. PMID 17240336.
Further reading
- Antonarakis SE (1998). "10 years of Genomics, chromosome 21, and Down syndrome.". Genomics 51 (1): 1–16. doi:10.1006/geno.1998.5335. PMID 9693027.
- Chen H, Rossier C, Morris MA, et al. (2000). "A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y.". Hum. Genet. 105 (5): 399–409. doi:10.1007/s004390051122. PMID 10598804.
- Guipponi M, Yaspo ML, Riesselman L, et al. (2000). "Genomic structure of a copy of the human TPTE gene which encompasses 87 kb on the short arm of chromosome 21.". Hum. Genet. 107 (2): 127–31. doi:10.1007/s004390000343. PMID 11030409.
- Wu Y, Dowbenko D, Pisabarro MT, et al. (2001). "PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase.". J. Biol. Chem. 276 (24): 21745–53. doi:10.1074/jbc.M101480200. PMID 11279206.
- Guipponi M, Tapparel C, Jousson O, et al. (2002). "The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family.". Hum. Genet. 109 (6): 569–75. doi:10.1007/s004390100607. PMID 11810268.
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